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NCT ID: NCT05055258 Recruiting - Clinical trials for Angioedema, Hereditary, Types I and II

Phase 2 Trial to Evaluate the Efficacy and Safety of 3 Doses of KVD824 for Prophylactic Treatment of HAE Type I or II

KVD824-201
Start date: September 17, 2021
Phase: Phase 2
Study type: Interventional

A study to assess whether different doses of KVD824 are effective in preventing attacks of Hereditary Angiodedema Type I or Type II.

NCT ID: NCT05053334 Not yet recruiting - Healthy Volunteers Clinical Trials

Biosimilar Study Comparing PK, PD, Safety and Immunogencity of BP11 With US Licensed Xolair and EU Approved Xolair

Start date: November 1, 2021
Phase: Phase 1
Study type: Interventional

A single dose, double blind comparative trial to assess the pharmacokinetics, pharmacodynamics, safety and immunogenicity of 3 different products (BP11, US-Xolair and EU-Xolair) containing 150mg of Omalizumab as subcutaneous injection in healthy male volunteers.

NCT ID: NCT05048056 Not yet recruiting - Atopic Dermatitis Clinical Trials

Phase 2 Study of Efficacy and Safety of AK120, in Subjects With Moderate-to-Severe Atopic Dermatitis

Start date: September 10, 2021
Phase: Phase 2
Study type: Interventional

This is a phase 2, multi-center, randomized, placebo-controlled, double-blind, parallel-group, dose-ranging study, conducted in subjects with moderate-to-severe atopic dermatitis.

NCT ID: NCT05047484 Completed - Healthy Clinical Trials

A Study of Multiple Doses of ALXN2050 in Healthy Adults

Start date: January 7, 2019
Phase: Phase 1
Study type: Interventional

This was a Phase 1, placebo-controlled, randomized, double-blind (participant and investigator blind, sponsor open), multiple-ascending dose study conducted in healthy participants to demonstrate the safety and tolerability and to evaluate the pharmacokinetics and pharmacodynamics of ACH-0145228 (ALXN2050).

NCT ID: NCT05047458 Completed - Healthy Clinical Trials

A Study of Single-dose ALXN2050 in Healthy Adults

Start date: November 28, 2017
Phase: Phase 1
Study type: Interventional

This was a phase 1, first-in-human, single-center, randomized, double-blind (participants and investigator blind, sponsor open) placebo-controlled, single-ascending dose study of ACH-0145228 (ALXN2050) conducted in healthy adult participants.

NCT ID: NCT05037929 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease

Start date: September 1, 2021
Phase: Phase 2
Study type: Interventional

This study will evaluate the efficacy, safety, and pharmacokinetics of astegolimab in combination with standard of care chronic obstructive pulmonary disease (COPD) maintenance therapy in patients with COPD who are former or current smokers and have a history of frequent exacerbations.

NCT ID: NCT05030909 Not yet recruiting - Clinical trials for Psychological Distress

Feasibility Study of a Group Intervention for Youths Impacted by the March 15th Attacks

Start date: August 30, 2021
Phase: N/A
Study type: Interventional

Psychological distress, anxiety and depression are common in adolescence, and even more so following traumatic events. On Friday 15 March 2019, two mosques in Christchurch were targeted in an act of terrorism, resulting in 71 people being injured and 51 people being shot dead. This has had widespread repercussions in the Muslim and wider community in Christchurch and New Zealand. Uptake of a response pathway set up by community and district health board groups has been low despite reports of high levels of distress in the adolescent population. The proposed study offers a transdiagnostic group treatment approach (ie. Targeting broad range of emotional difficulties) for teenagers affected by the March 15th shootings, incorporating a faith-based element based on Islamic psychology to address the local population's need. Investigators will assess the feasibility of this approach and offer the opportunity to screen and identify individuals in need of more intensive intervention. Investigators will run two gender-specific treatment groups (8 participants each) recruited from the community, with one individual session (for information and consent) and 5 group sessions. Self-report questionnaires will measure symptoms of emotional difficulties, trauma symptoms and functioning at baseline, end of treatment and at 3 months follow-up. In addition, participants will answer weekly brief measures to monitor for any increased distress.

NCT ID: NCT05021978 Recruiting - Essential Tremor Clinical Trials

A Clinical Trial of PRAX-944 in Participants With Essential Tremor

Start date: March 3, 2020
Phase: Phase 2
Study type: Interventional

This is a 2-part clinical trial to evaluate the efficacy, safety, and tolerability of 40 and 120 mg oral PRAX-944 compared to placebo in the treatment of adults with essential tremor. Part A is designed to study the dose titration from 20 to 40 mg every morning (QAM) (ie, 2 weeks with 7 days at each dose level). Part B is designed to study the dose titration from 20 to up to 120 mg QAM with at least 14 days of dosing at the highest tolerated dose for each participant. Blood levels of PRAX-944 will also be measured throughout the trial and pharmacokinetics will be evaluated.

NCT ID: NCT05011812 Recruiting - Covid19 Clinical Trials

Study of PBI-0451 in Healthy Subjects.

Start date: August 16, 2021
Phase: Phase 1
Study type: Interventional

This is a phase 1, placebo-controlled, blinded, randomized, dose escalation study of PBI-0451 in healthy subjects. PBI-0451 is a new chemical entity and inhibitor of the main protease of coronaviruses, including the SARS-CoV-2 that causes COVID-19 disease. The study is designed to evaluate the safety, tolerability and pharmacokinetics of PBI-0451 after single and multiple ascending doses and also to explore drug-drug interaction potential of PBI-0451.

NCT ID: NCT05004129 Enrolling by invitation - Clinical trials for Congenital Myotonic Dystrophy

Safety and Efficacy of Tideglusib in Congenital Myotonic Dystrophy

REACH CDM X
Start date: August 2021
Phase: Phase 2/Phase 3
Study type: Interventional

This is an open-label extension phase 2/3 study for children and adolescents with Congenital Myotonic Dystrophy (Congenital DM1) who participated in and completed the preceding AMO-02-MD-2-003 study.