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NCT ID: NCT02444182 Completed - Periodontal Health Clinical Trials

Effects of Probiotics on Oral Health

Start date: December 2014
Phase: Phase 1/Phase 2
Study type: Interventional

Some probiotics have been shown to have preventive effects on infectious diseases and allergies. Because their long-term enhancement of the immune responses of children, they have been recommended for infants in some countries. The most promising ones seem to be the combination of Bifidobacterium lactis BB-12 and Lactobacillus rhamnosus GG. Probiotic microbes are mainly ingested orally and the gastrointestinal tract is thus the primary target organ for them. However, the mouth is the first part of the gastrointestinal tract. Most probiotics are in theory cariogenic, thus their effects on oral health should be known. Several probiotics decrease levels of salivary mutans streptococci (MS), but in other respects very little is known about their effects on the oral microbiota. Also effects of probiotics on dental plaque should be studied. This study aims to find out the effects of the combination of BB-12 and LGG, delivered with a lozenge (4 weeks, twice a day) with a mixture of them on the amount of plaque and gingival health

NCT ID: NCT02418520 Completed - Periodontitis Clinical Trials

The Effect of Miswak Chewing Sticks on the Oral Helicobacter Pylori Infection

Miswak
Start date: October 1, 2019
Phase: N/A
Study type: Interventional

To elucidate the relationship of chewing miswak sticks on the H. Pylori infection in the oral cavity.The study would be conducted at the Faculty of Dentistry, Kuwait University. Oral plaque samples would be obtained from those patients who are willing to participate. As a part of the initial screening the plaque samples would be collected and sent for screening of oral microbiota to the Microbiology Department of Faculty of Dentistry, Kuwait University. Here, the basic microbial culturing (rapid urease test) would be performed for detecting the presence of oral H.Pylori. Volunteers who are tested positive for H. Pylori infection through the rapid urease test would be invited to participate in the study.

NCT ID: NCT02410200 Completed - Clinical trials for Multiple Sclerosis, Relapsing-Remitting

Study of the Effect of BG00012 on MRI Lesions and Pharmacokinetics in Pediatric Subjects With RRMS

FOCUS
Start date: September 30, 2015
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to evaluate the effect of BG00012 (dimethyl fumarate) on brain magnetic resonance imaging (MRI) lesions in pediatric participants with relapsing-remitting multiple sclerosis (RRMS). The secondary objectives of this study are to characterize the pharmacokinetics of BG00012 in pediatric participants with RRMS and to evaluate the safety and tolerability of BG00012 in pediatric participants with RRMS.

NCT ID: NCT02322762 Completed - Clinical trials for Type 2 Diabetes Mellitus

DISCOVERing Treatment Reality of Type 2 Diabetes in Real World Settings

DISCOVER
Start date: December 30, 2014
Phase:
Study type: Observational

DISCOVER is a Non Interventional Study study to describe the disease management patterns and clinical evolution over three years in type 2 diabetes mellitus patients initiating a second line anti-diabetic treatment.

NCT ID: NCT02210819 Completed - Clinical trials for Deep Vein Thrombosis (DVT)

Treatment of Venous Thromboembolism (VTE) With Either Rivaroxaban or Current Standard of Care Therapy

XALIA LEA
Start date: June 27, 2014
Phase:
Study type: Observational

Following the findings of the clinical trials in drug development, this global non-interventional cohort field study will investigate rivaroxaban under clinical practice conditions in comparison with current standard of care for patients with acute venous thoromboembolism (VTE). The main goal is to analyze long-term safety in the use of rivaroxaban in the treatment of acute VTE in routine clinical practice.

NCT ID: NCT02153411 Completed - Asthma Clinical Trials

Multicentric, Transversal, Descriptive, Epidemiological Study on the Management of Asthma in Asthmatic Middle East Adult Population

ESMAA
Start date: June 2014
Phase: N/A
Study type: Observational

Descriptive study on the management of asthma in asthmatic Middle East adult population : Algeria,Egypt, Irak,Iran, Jordan, Koweit, Lebanon, Qatar,Saudi,Tunisia, UAE

NCT ID: NCT02024139 Completed - Clinical trials for Pain Associated With Fixed Orthodontic Treatment

Efficacy of Chewing Sugarless Gum for Reduction of Orthodontic Appliance Pain

Start date: January 2014
Phase: N/A
Study type: Interventional

This study investigates whether chewing sugar-free chewing gum can reduce pain associated with braces treatment. The study collects pain scale records for 10 consecutive days after placement of braces. No changes to patients routine braces treatment is done. All materials used are available over the counter.

NCT ID: NCT01985607 Completed - Protein Allergy Clinical Trials

Efficacy of a New Thickened Extensively Hydrolyzed Formula

ALLAR
Start date: February 2011
Phase: N/A
Study type: Interventional

Cow Milk Allergy (CMA) occurs in 2 to 5 % of all infants. Reflux, regurgitation and vomiting are well recognised symptoms of CMA. The recommended treatment of CMA is an extensive hydrolysate. The North American Society of Pediatric Gastroenterology Hepatology and Nutrition (NASPGHAN) & the European Society of Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) reflux guidelines have no strict recommendations for the treatment of distressed infants with reflux, suspected of CMA. One of the preferred proposed options is to thicken an extensive hydrolysate . This study aims at evaluating the additional value of a thickened extensive hydrolysate in children suspected of CMA and presenting with frequent regurgitation.

NCT ID: NCT01980459 Completed - Clinical trials for Non-Insulin Dependent Diabetes Mellitus

Magnesium Treatment of Inflammation in Disorders of Glucose Homeostasis

MagInGlu
Start date: October 2013
Phase: Phase 1
Study type: Interventional

In most diabetic patients where low blood magnesium levels occur the important depletion of cellular levels is usually not measured. This study will measure both blood and oral mucosal cell magnesium levels before and after 3 months of supplementation with magnesium tablets (the recommended dietary amount of 336 milligrams per day). These magnesium levels will be correlated with blood levels of indicators of inflammation (eg C reactive protein) to see whether the cellular levels are more reliable than blood levels of magnesium for appropriate treatment of magnesium deficiency in diabetic patients.

NCT ID: NCT01950819 Completed - Hemodialysis Clinical Trials

Advancing Renal TRANSplant eFficacy and Safety Outcomes With an eveRolimus-based regiMen (TRANSFORM)

TRANSFORM
Start date: December 3, 2013
Phase: Phase 4
Study type: Interventional

This is a 2-year, randomized, multicenter, open-label, 2-arm study evaluating the graft function of everolimus and reduced CNI versus MPA and standard CNI in adult de novo renal transplant recipients.