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NCT ID: NCT04922710 Terminated - Clinical trials for Adverse Childhood Experiences

Physical Exercise for Augmenting Cognitive Health (PEACH)

PEACH
Start date: January 4, 2022
Phase: Early Phase 1
Study type: Interventional

PEACH is a pilot project which is being conducted to determine the feasibility and acceptability of a 12-week home-based exercise intervention among Black and African American adults. A secondary aim of the project is to determine whether the exercise intervention improves cognitive and psychological functioning.

NCT ID: NCT04806152 Terminated - Sarcopenia Clinical Trials

Sarcopenia and Combined-modality Exercise

Start date: May 2, 2017
Phase: N/A
Study type: Interventional

This study examined the effects of combined-modality exercise training (resistance, endurance, flexibility and balance) on muscle mass, muscle function and physical activity in community-dwelling elderly living in Jamaica who had been characterised as having sarcopenia.

NCT ID: NCT01601340 Terminated - Sickle Cell Disease Clinical Trials

Effects of HQK-1001 in Patients With Sickle Cell Disease

Start date: July 2012
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effects of HQK-1001 on Hb F in subjects with sickle cell disease.

NCT ID: NCT01531387 Terminated - Sickle Cell Anemia Clinical Trials

Sparing Conversion to Abnormal TCD (Transcranial Doppler) Elevation (SCATE)

SCATE
Start date: May 2012
Phase: Phase 3
Study type: Interventional

The primary goal of the Phase III SCATE trial is to compare 30 months of alternative therapy (hydroxyurea) to standard care (observation) in children with sickle cell anemia and conditional (170 - 199cm/sec) Transcranial Doppler (TCD) velocities. For the alternative regimen (hydroxyurea) to be declared superior to the standard treatment regimen (observation), the hydroxyurea-treated group must have a three-fold reduction in the incidence of conversion to abnormal TCD velocities (≥ 200 cm/sec), compared to the standard treatment arm.

NCT ID: NCT01115010 Terminated - Colonoscopy Clinical Trials

Effectiveness of Stiffening Wire in Colonoscopy With Pre-Owned Colonoscopes

Start date: December 2009
Phase: N/A
Study type: Interventional

The study aims to determine whether a proprietary, FDA approved stiffening wire improves the efficiency of colonoscopy (that is, decreases the duration of the procedure) and/or enables complete visualization of the colon in a greater proportion of cases (than when the procedure is performed without it) with old, used colonoscopes. Colonoscopes are designed with a delicate balance between stiffness and flexibility. Stiffness helps to prevent curling (looping) of the colonoscope in those sections of the colon that are not fixed to the wall of the abdominal cavity and flexibility enables successful negotiation of bends or flexures in the colon. As colonoscopes age, they lose stiffness and this makes it very challenging to advance the colonoscope all the way to the cecum (the upper end of the colon). Even when the cecum is successfully reached, it may take an inordinately long time. In Jamaica, most endoscopists (General Surgeons and Gastroenterologists) use older, pre-owned colonoscopes imported from the USA, because the average patient and local health insurance companies cannot bear the level of fees that would enable cost recovery for new equipment. The stiffening wires (in two grades of stiffness) used in this study are passed through the biopsy channel of the colonoscope only after its tip has passed the upper end of the descending colon and entered the transverse colon. The device is safe when used as recommended by the manufacturers (and approved by the FDA), and does not appear to increase risk over and above the risk of colonoscopy with the unassisted colonoscope. Although the device clearly improves the stiffness of the colonoscope, there is no research evidence that it actually works in practice, either to improve cecal intubation rate or to decrease procedure time. It is therefore also unclear whether the possible benefit of using the device is achieved if introduced at the first opportunity allowed by the manufacturers or only after difficulty is encountered with the unassisted colonoscope. In this study, patients are randomly assigned to one of 3 "interventions". One group has colonoscopy performed with the colonoscope alone and the wires are only introduced if there is difficulty advancing the colonoscope after it has passed into the transverse colon ("difficulty" defined as failure to advance the tip of the colonoscope after 5 minutes). In the 2nd and 3rd groups, the assigned wire will be introduced as soon as the colonoscope enters the transverse colon and is removed if "difficulty" is encountered, as defined above. The different phases of colonoscopy will be timed with a stop watch and when a sufficient number of patients has been accrued, the investigator will be able to compare the time it takes to complete the procedure with and without the wires as well as the proportion of cases in which the cecum was reached with and without the assistance of the wires.

NCT ID: NCT00102791 Terminated - Sickle Cell Disease Clinical Trials

A Stratified Sickle Event Randomized Trial (ASSERT)

ASSERT
Start date: February 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the effects of ICA-17043 to placebo with or without hydroxyurea (an oral drug used for treatment of sickle cell disease) in patients with sickle cell disease who have had 2 or more acute sickle-related painful crises requiring a visit to a medical facility within the past 12 months.