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NCT ID: NCT05051462 Active, not recruiting - Clinical trials for Mild to Moderate Psychopathological Symptoms

Efficacy of Family Constellations in the General Population

Start date: July 19, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the efficacy of systemic / family constellation therapy in improving mild-moderate psychopathological symptoms and overall wellbeing in the general population. Given the limited amount of evidence on this therapeutic method, special attention will be given to monitor potential adverse outcomes to establish intervention safety. The study will use a randomized, wait-list controlled design and a 6-month follow-up time. This is the second study of this nature following a similar study from Germany.

NCT ID: NCT05048719 Not yet recruiting - Type 2 Diabetes Clinical Trials

A Study of LY3502970 in Participants With Type 2 Diabetes Mellitus

Start date: September 15, 2021
Phase: Phase 2
Study type: Interventional

The main purpose of this study is to evaluate the efficacy and safety of LY3502970 in participants with type 2 diabetes (T2D) who failed to achieve adequate glycemic control on diet and exercise alone or on a stable dose of metformin. This study will last about 30 weeks.

NCT ID: NCT05033171 Active, not recruiting - Clinical trials for Scoliosis Idiopathic

Rod Shape Changing After Scoliosis Correction Surgery

Start date: September 1, 2019
Phase: N/A
Study type: Interventional

The change of the fixation-rod after posterior srew-rod fixation segmentdesis is not widely known. The recent development of the 3D scanning technics and the opportunities of the EOS 2D/3D system made us possible to have the exact rod shape immediately after implantation, and at each control examination. These progressions made us available to follow up the shape changing of the fixation-rod, hereby the changing of the correction.

NCT ID: NCT05015725 Not yet recruiting - Hypothyroidism Clinical Trials

The Relationship Between Serum rT3 Concentrations, T3/T4 Ratio, and Symptoms/Quality of Life in Treated Hypothyroid Patients

Start date: September 1, 2021
Study type: Observational

The aim of this study is to evaluate the relationship between serum rT3 (serum reverse triiodothyronine) concentrations, T3/T4 (triiodothyronine/thyroxine) ratio, and persistent symptoms /quality of life in treated hypothyroid patients. Investigators are going to measure TSH (thyroid stimulating hormone), free-T3, free-T4, reverse-T3 levels, biochemical markers of hypothyroidism and quality of life (assessed by validated questionnaires).

NCT ID: NCT05011513 Recruiting - COVID-19 Clinical Trials

A Study of PF-07321332/Ritonavir in Non-hospitalized Low-Risk Adult Participants With COVID-19

Start date: August 25, 2021
Phase: Phase 3
Study type: Interventional

The primary hypothesis to be tested is whether or not there is a difference in time to sustained alleviation of all targeted COVID-19 signs and symptoms through Day 28 between PF-07321332/ritonavir and placebo.

NCT ID: NCT05009563 Recruiting - Clinical trials for Coronavirus Infection

COvid iMaging With POSitron Emission Tomography

Start date: January 4, 2021
Phase: N/A
Study type: Interventional

We aim to study if metabolic intensity and extent according to pathologic pulmonary 18F-2-fluoro-2-deoxy-D-glucose (FDG)-uptake may correlate with the course of COVID-19 pneumonia and potentially yield prognostic value. Moreover, we aim to assess permanent changes after Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, such as pulmonary fibrosis and neuropsychiatric symptoms (anosmia, depression, fatigue) where evaluation with FDG-positron emission tomography (PET/CT) might have an impact on further patient care.

NCT ID: NCT05005858 Recruiting - Clinical trials for Alveolar Bone Resorption

Modified Ridge Splitting Technique Using Autogenous Bone Blocks (MRS)

Start date: May 14, 2019
Phase: N/A
Study type: Interventional

In this clinical study ridge splitting procedures are preformed using autogenous bone blocks. After a 3-month healing, at the time of dental implant placement bone core biopsy samples are harvested. The samples undergo micro-Ct and histomorphometric analysis.

NCT ID: NCT05004844 Not yet recruiting - Clinical trials for Trauma Induced Coagulopathy

Mitochondrial Dysfunction in Trauma-related Coagulopathy

Start date: August 31, 2021
Study type: Observational

Bleeding control often poses a great challenge for clinicians due to trauma-induced blood clotting disorder (TIC), a condition that is present in one-third of bleeding trauma patients. As platelets are considered as central mediators in TIC, the understanding of mitochondria-mediated processes in thrombocytes may disclose new therapeutic targets in the management of severely injured patients. The investigators hypothesize that mitochondrial dysfunction occurs in the platelets of trauma patients with TIC. The investigators intend to quantitatively characterize the derangements of mitochondrial functions in TIC; and assess the relation between mitochondrial respiration and clinical markers of platelet function

NCT ID: NCT04988386 Not yet recruiting - Clinical trials for Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy

Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants

Start date: October 23, 2021
Phase: Phase 3
Study type: Interventional

Open-Label Extension and Safety Monitoring Study of Acoramidis (AG10) in Participants with Symptomatic Transthyretin Amyloid Cardiomyopathy Who Completed the Phase 3 ATTRibute-CM Trial (AG10-301)

NCT ID: NCT04987411 Not yet recruiting - Trauma Clinical Trials

Detection of Exhaled Methane Levels in Hemorrhagic Shock

Start date: August 1, 2021
Study type: Observational

This prospective observational study aims to test the efficacy of the continuous measurement of exhaled methane levels in monitoring the hemodynamic state of severely injured, bleeding trauma patients.