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NCT ID: NCT06280157 Enrolling by invitation - Clinical trials for Group B Streptococcus Infection

A Follow up Study of Group B Streptococcus Vaccine (GBS-NN/NN2 Vaccine) in Healthy Volunteers

Start date: January 18, 2024
Phase:
Study type: Observational

The goal of this follow-up study is to investigate the persistence of the immune response induced by the GBS-NN/NN2 vaccine in women who have participated in study MVX0002, and/or in study MVX0003 with GBS-NN/NN2 vaccine and received 1, 2 or 3 doses of GBS-NN/NN2. The main question it aims to answer is to determine the persistence of the immune response induced by the GBS-NN/NN2 vaccine by measuring antibody concentrations. Participants who had received a primary course of GBS-NN/NN2 in Study MVX0002 and/or MVX0003 will be invited to return to have a single yearly blood sample of approximately 10 mL collected 2 to 5 years after the completion of the previous vaccination.

NCT ID: NCT06262399 Enrolling by invitation - Clinical trials for Hereditary Angioedema

Long-Term Follow-Up (LTFU) of Subjects Treated With NTLA 2002

Start date: April 12, 2024
Phase:
Study type: Observational

This is a follow-up study of subjects who received NTLA-2002 in a previous clinical trial as an observational evaluation of the long-term effects of the investigational therapy.

NCT ID: NCT06237426 Enrolling by invitation - Clinical trials for Post Traumatic Stress Disorder

An Evaluation of the Long-term Efficacy and Safety of Methylone for the Treatment of PTSD

IMPACT-EXT
Start date: March 6, 2024
Phase: Phase 2
Study type: Interventional

This is an extension study of participants who previously completed a Transcend-sponsored clinical trial with methylone as a treatment for PTSD (IMPACT-1 or IMPACT-2). Participants will be followed for up to 52 weeks. During the 52 week period, PTSD symptoms and safety will be assessed monthly. Participants' PTSD symptoms will be assessed at each observational visit and if criteria for Relapse has been met, participants may be eligible to receive a course of methylone treatment. After a course of methylone treatment, participants resume observational study visits until Week 52.

NCT ID: NCT06230354 Enrolling by invitation - Clinical trials for EGPA - Eosinophilic Granulomatosis With Polyangiitis

Explore the Efficacy and Mechanism of Action of Tezepelumab in Eosinophilic Granulomatosis With Polyangiitis

RACEMATE
Start date: May 2024
Phase: Phase 2
Study type: Interventional

RACEMATE is a phase 2b, multicentre, randomised, double-blinded, placebo-controlled study designed to explore the efficacy and mechanism of action of tezepelumab in adults with eosinophilic granulomatosis with polyangiitis (EGPA).

NCT ID: NCT06222346 Enrolling by invitation - Clinical trials for Subthreshold Depression

Online Peer Support in Long-term Conditions

Start date: February 12, 2024
Phase: N/A
Study type: Interventional

Over 15 million people in England live with a long-term physical health condition. Low mood, loneliness and worry related to chronic illness are very common. In partnership with people with long-term conditions we have co-designed an online peer support platform to help people with health problems connect, support others, share experiences, and receive evidence-based information and advice on self-management. This study explores if the platform is feasible to implement and acceptable for people with long-term conditions experiencing mild depressive symptoms. Those allocated to the intervention arm will be invited to try out an online peer support platform with psychoeducational resources named "CommonGround". Those in the control arm will be guided to use the National Health Service NHS "Mental Health" webpages.

NCT ID: NCT06173635 Enrolling by invitation - Healthy Volunteers Clinical Trials

A Comparison Study of the Maxi Move 5 (MM5) Device

Start date: December 20, 2023
Phase: N/A
Study type: Interventional

This trial aims to evaluate the added improvements from a caregiver and patient benefit perspective. The trial should identify the forces involved for the caregiver when manoeuvring the lift.

NCT ID: NCT06164951 Enrolling by invitation - Achondroplasia Clinical Trials

A Study to Evaluate the Efficacy and Safety of Infigratinib in Children and Adolescents With Achondroplasia

PROPEL3
Start date: November 10, 2023
Phase: Phase 3
Study type: Interventional

This is a Phase 3, multicenter, double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of infigratinib in children and adolescents with achondroplasia (ACH) who have completed at least 26 weeks of participation in the QED-sponsored study PROPEL (QBGJ398-001).

NCT ID: NCT06163222 Enrolling by invitation - Clinical trials for Behavioural Science Interventions to Improve Health Equity

Behavioural Interventions to Improve Equity in Outpatient Access

Start date: January 8, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to improve health equity within outpatient service access. This is through design and behavioural science-informed interventions that aim to improve rates of first outpatient appointment attendance. Health equity refers to the avoidable and unfair differences in health access, outcomes and experience between groups or populations. Outpatient services are those appointments where advice from a specialised medical professional is provided to a patient in a clinic setting. This clinical trial aims to test different ways of supporting people to attend their first outpatient appointments at five clinical specialties (ophthalmology, gastroenterology, colorectal surgery, cardiology and plastic surgery) at Imperial College Healthcare NHS Trust (ICHT). It is specifically focused on improving attendance for people who are most likely to miss their appointment based on ICHT data, which includes people from minority ethnic backgrounds and people living in the most deprived postcodes. The main question this clinical trial aims to answer is: • Do behavioural science-informed text message interventions improve rates of first outpatient appointment attendance in patients facing inequity of access based on ethnicity and deprivation? The secondary questions this clinical trial aims to answer include: - Do behavioural science-informed text message interventions improve rates of first outpatient appointment attendance across all patient groups? - Do behavioural science-informed text message interventions increase the number of patients who "self-cancel" their appointment if they need to? - In which patient groups did the text message interventions have most impact, e.g., a certain age range? - Which factors were associated with improved outpatient attendance rates specifically in participants from minority ethnic groups or living in area with highest level of deprivation? - What was the overall outcome of all first outpatient appointments included in the clinical trial? - What was the overall successful text message delivery rate for the messages sent as part of the study? Were there particular participant groups that were more likely to have an undelivered text message? - How well did participants engage with the text message interventions e.g. did they click the link provided in the text message?

NCT ID: NCT06162689 Enrolling by invitation - Clinical trials for Perinatal Psychiatry

Psychiatry Research and Motherhood at 6 to 8 (PRAM-P@6to8)

PRAM-P@6to8
Start date: January 3, 2024
Phase:
Study type: Observational

The goal of this observational study is to examine the relationship between severe perinatal maternal mental illness and stress reactivity and general development of children aged 6 to 8 years. Mothers were previously recruited and assessed during pregnancy and their babies were assessed at 6 days, 8 weeks and 12 months post delivery. This follow-up will assess the occurrence of any psychiatric episodes (e.g., depression, mania, psychosis) in the intervening period. Assessments of the children will include evaluation of their response to a mildly stressful procedure, as well as their physical, cognitive and social-emotional development, and their mental health. Possible factors that may moderate the relationship between the mother's perinatal mental health and the child's stress reactivity and development, including the home environment, adversity, parent-child interaction and maternal and paternal (or co-parent) mental health will also be assessed.

NCT ID: NCT06156618 Enrolling by invitation - Dental Erosion Clinical Trials

The Effect of Nitrate Supplement on the Oral Microbiome and Saliva in Dental Erosion

Start date: November 1, 2023
Phase: N/A
Study type: Interventional

Dental erosion happens when teeth lose some of their parts because of acid from the things people eat and/or drink or even from their stomach. It can make their teeth hurt and become sensitive. The mouth has a protective shield called salivary pellicle that helps, and there are some special bacteria called Nitrate-reducing bacteria (NRB) that can be good for the mouth and heart. Eating some fruits and vegetables or drinking beetroot can make these bacteria thrive, which might help the heart and blood pressure. This study wants to see how drinking beetroot juice affects these good bacteria in your mouth for people with healthy teeth and those with erosion. This study aims to find out if drinking beetroot juice can change the saliva and bacteria in the mouth for the better, in people with both healthy teeth and those with dental erosion. The proposed study is part of a PhD educational project and will be a double blind, randomised design, crossover trial for the effect of nitrate supplement on healthy control and people with dental erosion (PwDE). This study aims to explore the effect of nitrate supplement on oral microbiome in WMS and SP and its impact on blood pressure and arterial stiffness in healthy controls and PwDE.