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NCT ID: NCT05475652 Active, not recruiting - Elderly Clinical Trials

The Influence of Manual Therapy Applied to the Cervical Spine in the Prevention of Balance Disorders in the Elderly

ManEq
Start date: February 4, 2020
Phase: N/A
Study type: Interventional

Falling is a major trauma that can occur with aging, leading to very significant psychological and physical health effects with financial and societal consequences. It is therefore essential to explore therapeutic treatments that can reduce this risk. Some recognized effective treatments exist, concerning in particular the re-education of the muscles of the lower limbs. However, to our knowledge, none of them focus on the cervical spine although the latter is located at an essential physiological crossroads. Manual therapy, which has already demonstrated its impact on pain and balance parameters in the elderly, could be a painless and non-invasive tool of choice in addressing this problem.

NCT ID: NCT05475483 Active, not recruiting - Huntington Chorea Clinical Trials

Efficacy and Safety on SOM3355 in Huntington's Disease Chorea

Start date: August 2, 2022
Phase: Phase 2
Study type: Interventional

Phase IIb, randomized, double-blind, placebo-controlled study in parallel groups assessing the efficacy and safety of two doses of SOM3355 in patients suffering from Huntington's Disease with choreic movements.

NCT ID: NCT05469867 Active, not recruiting - Glaucoma Eye Clinical Trials

Pivotal Trial for a Synthetic Tissue Substitute for Concealment of Artificial Ocular Implants

EverPatch
Start date: August 16, 2022
Phase: N/A
Study type: Interventional

This clinical trial will assess the clinical safety and performance of the CorNeat EverPatch device used as a tissue substitute for concealment of artificial ocular implants.

NCT ID: NCT05469737 Active, not recruiting - Clinical trials for Myelodysplastic Syndromes

A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Participants With International Prognostic Scoring System Revised (IPSS-R) Low- or Intermediate-risk Myelodysplastic Syndrome (MDS)

Start date: December 14, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of oral azacitidine in participants with low to intermediate International Prognostic Scoring System Revised (IPSS-R) myelodysplastic syndrome (MDS).

NCT ID: NCT05469503 Active, not recruiting - Metabolic Syndrome Clinical Trials

Effect of TOTUM-854 on Blood Pressure in Subjects With Moderately Elevated Blood Pressure

INSIGHT
Start date: July 15, 2022
Phase: N/A
Study type: Interventional

This clinical study aims to assess the efficacy of TOTUM-854, a mix of 6 plant extracts, consumed twice a day on automated office blood pressure in subjects with moderately elevated blood pressure. The hypothesis is that TOTUM-854 is superior to placebo for decrease of automated office blood pressure after 12 weeks of consumption.

NCT ID: NCT05469360 Active, not recruiting - Alzheimer Disease Clinical Trials

Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Participants

Start date: February 23, 2023
Phase: Phase 1
Study type: Interventional

Phase 1b study to assess the pharmacodynamics, safety, tolerability, and pharmacokinetics of NIO752 in patients with early Alzheimer's disease (AD)

NCT ID: NCT05462990 Active, not recruiting - Clinical trials for Osteoarthritis, Knee

A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA

Start date: November 9, 2022
Phase: Phase 2
Study type: Interventional

The purpose of the study is to find out if the investigational treatment named QUC398 has beneficial effects on osteoarthritis knee pain and knee cartilage, and if it is safe and well tolerated.

NCT ID: NCT05462717 Active, not recruiting - Clinical trials for Advanced Solid Tumor

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

Start date: September 19, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of escalating doses of RMC-6291 (KRAS G12C(ON) inhibitor) monotherapy in adult subjects with advanced solid tumors and to identify the maximum tolerated dose (MTD), and the recommended Phase 2 dose.

NCT ID: NCT05461521 Active, not recruiting - Clinical trials for Stress Disorders, Post-Traumatic

Improving FAMily Members' Experience in the ICU

FAME
Start date: December 15, 2022
Phase:
Study type: Observational

The aim of the present research is to set up a large multicentric, prospective cohort of family members of patients admitted to intensive care. The data collected will concern the patients and their family members, the caregivers and the functioning of the services during the collection period. This cohort will allow: 1. to carry out a quantitative evaluation of post-traumatic stress disorder (PTSD) in a large number of family members, to determine the risk factors in relation to the characteristics of the family members, and to define a predictive model of PTSD in this population 2. to determine the factors related to the operating conditions of the resuscitation services that favor the occurrence of PTSD in the family members, 3. to create a biological bank from blood samples taken from family members, 4. to carry out a qualitative study allowing a psychological and sociological analysis of the experience of the family members concerning the hospitalization in intensive care of their loved one.

NCT ID: NCT05458856 Active, not recruiting - Prostate Cancer Clinical Trials

Effects of Triptorelin When Given Every 6-months Under the Skin to Adult Males With Cancer in the Prostate

TriptoSwitch
Start date: August 30, 2022
Phase: Phase 3
Study type: Interventional

The aim of the study is to determine if triptorelin formulated for use every 6 months (given twice during the study) is effective and safe for when given by injection under the skin for the treatment of adult males with cancer in the prostate.