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Clinical Trial Summary

Cough is the most common reason why people seek medical attention in developed countries. The main mechanisms for prolonged cough are hypersensitivity of the cough reflex arc, sputum production, and constriction of the airway smooth muscles. Recognition of the mechanism in each cough patient is essential for the efficient management of prolonged cough. At present, there are no feasible tests for everyday clinical work to recognize cough reflex arc hypersensitivity. Mannitol test was originally developed for asthma diagnostics. We have recently shown that it can also be used to investigate hypersensitive cough reflex arc. The purpose of the present study is to create reference ranges for normal cough responsiveness to inhaled mannitol. Without them, the test cannot be utilized in everyday clinical work. For that purpose we will perform mannitol test in 140 subjects, who are at least 18 years old and without any chronic respiratory symptoms or disorders. The subjects will be recruited in three centers: University of Eastern Finland and two Australian hospitals: John Hunter Hospital and Royal Prince Alfred Hospital.The material will be collected 1.9.2021-31.12.2022. We apply funding for both personnel and material expences, to carry out this study.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05034367
Study type Interventional
Source Kuopio University Hospital
Contact Heikki O Koskela, MD
Phone +358 447172795
Email [email protected]
Status Recruiting
Phase N/A
Start date September 2021
Completion date December 2022

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