The Effect of Dexmedetomidine for Emergence Cough

Cough Clinical Trial

Official title:

The Effect of Dexmedetomidine on the Remifentanil Concentration for Preventing Cough During Emergence After Propofol Anesthesia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03622502
• Other study ID #: AJIRB-MED-OBS-18-170
• Status: Completed
• Phase: N/A
• Start date: August 16, 2018
• Est. completion date: March 27, 2019

Study information

• Verified date: January 2020
• Source: Ajou University School of Medicine
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Dexmedetomidine or remifentanil are effective in attenuating cough during peri-extubation period after general anesthesia. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence.

Description:

Administration of dexmedetomidine before end of surgery could reduce airway reflexes and hemodynamic changes during tracheal extubation. Compared with remifentanil alone, administration of dexmedetomidine in combination with remifentanil is effective in relieving cough and hemodynamic changes without inhibition of respiration. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence using the modified up-and-down method.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 48
• Est. completion date: March 27, 2019
• Est. primary completion date: March 22, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 65 Years

Eligibility

Inclusion Criteria:

• ASA physical status I or II undergoing endoscopic sinus surgery or septoplasty under general anesthesia

Exclusion Criteria:

• predicted difficult airway

• body mass index > 35 kg/m2,

• recent upper respiratory infection

• asthma

• current smoker

• patients using angiotensin converting enzyme-inhibitors

• uncontrolled hypertension

Related Conditions & MeSH terms

• Cough

Intervention

Drug:
• Dexmedetomidine
Dexmedetomidine 0.5mcg/kg was infused over 10 min before end of the surgery
• Remifentanil
Remifentanil was maintained at predetermined effect-site concentration during the periextubation period (initial concentration: 2.0 ng/ml)
• Normal saline
Normal saline was infused over 10 min before end of the surgery

Locations

Country	Name	City	State
Korea, Republic of	Ajou University Hospital	Suwon	Gyeongki-do

Sponsors (1)

Lead Sponsor	Collaborator
Ajou University School of Medicine

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of cough	Number of cough or a strong and sudden contraction of the abdomen during periextubation periextubation periods	from end of surgery to 5 min after tracheal extubation]