Cough Clinical Trial - Pulmozyme for Sjogren's Associated Cough

Status Withdrawn

Clinical Trial Summary

Patients with Sjogren's disease have destruction of the mucus secreting cells in the airway. This manifestation of the disease leads to the common complaint of persistent dry cough that is seen in many of these patients. This study is aimed at determining whether the regular use of Pulmozyme will result in decreased cough and improved quality of life.

Clinical Trial Description

Patients with Sjogren's disease have destruction of the mucus secreting cells in the bronchi. This manifestation of the disease leads to the common complaint of persistent dry cough that is seen in many of these patients. The investigators theorize that regular use of Pulmozyme will result in decreased cough and improved quality of life, by improving mucus clearance.

Primary Objective:To determine if the use of Pulmozyme, twice a day improves cough-related quality of life or cough severity in patients with chronic cough due to Sjogren's disease.

Secondary Objectives:

1. To determine the DNA content in sputum from patients with chronic cough due to Sjogren's disease.

2. To determine the effect of Pulmozyme use on pulmonary function in patients with chronic cough due to Sjogren's disease.

3. To determine the safety of Pulmozyme, taken twice a day in patients with chronic cough due to Sjogren's disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01357447
Study type	Interventional
Source	UConn Health
Contact
Status	Withdrawn
Phase	Phase 1
Start date	May 2011
Completion date	March 2012

View Details

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