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Cortisol clinical trials

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NCT ID: NCT05760872 Recruiting - Cortisol Clinical Trials

Effect of MIST on Esophageal Sensitivity: Pilot Study

PilotMIST
Start date: November 4, 2021
Phase:
Study type: Observational

Influence of placing the esophageal probe on the cortisol response. Number of cortisol (non)responders and association of heart rate and subjective perception of stress with cortisol levels.

NCT ID: NCT05580874 Completed - Stress Clinical Trials

The Effect of Massage on Stress in Premature Babies

Start date: June 17, 2022
Phase: N/A
Study type: Interventional

The practices of the neonatal intensive care unit that reduce the stress of premature babies and respond to behavioral cues have a positive effect on the development of newborns. The stress experienced by premature infants affects the baby's behavior and laboratory findings. Massage is an effective application in facilitating the adaptation of premature babies to extrauterine life and ensuring that they are least affected by adverse environmental conditions. Massage in premature babies has an important place in reducing stress and supporting psychological, mental and physiological development as a healthy tactile stimulus.

NCT ID: NCT04563676 Recruiting - Covid19 Clinical Trials

Physiopathology and Sequelae of COVID-19 Infection

SEQ-COV-PHYSIO
Start date: September 22, 2020
Phase: N/A
Study type: Interventional

The data obtained from Covid-19 infections seem to suggest that the immunogenesis of Covid-19 could in some cases be the result of immune dysregulation. On the other hand, endocrine damage is possible at the tile of Covid-19 infection (mainly thyroid,adrenal, and hypothalamus). These disorders are autoimmune or linked to degeneration. The main objective is to assess the thyroid function (thyrotropic axis) as well as the corticotropic adrenal function of patients who have had Copvid-19 pneumonia. The secondary objectives is to describe the pathophysiological mechanisms of pulmonary and vasculothrombotic involvement of Covid-19

NCT ID: NCT04544254 Completed - Cortisol Clinical Trials

Effectivity of Bilateral Transversus Thoracis Muscle Plane Block After Open Heart Surgery

Start date: October 15, 2020
Phase: N/A
Study type: Interventional

This Study aimed to assess The Effectivity of Bilateral Transversus Thoracis Muscle Plane Block to Reduce Pain and Stress Response After Open Heart Surgery

NCT ID: NCT04514731 Recruiting - Arthropathy of Knee Clinical Trials

Magnesium Sulfate and Neuroendocrine Hormone

Start date: January 21, 2021
Phase: Phase 4
Study type: Interventional

Total knee arthroplasty is a procedure that relieves pain in patients with severe symptomatic osteoarthritis, but it can be associated with postoperative pain, which hinders recovery. In the previous study, we reported evidence of increased pain in patients undergoing staged total knee arthroplasty, in whom the second operated knee had greater sensitivity (tertiary hyperalgesia) as a result of the surgical injury to the first operated knee. Magnesium sulfate is an effective analgesic adjuvant for postoperative pain. Its analgesic property seems to be associated with the regulation of calcium influx into the cells, or antagonism of N-methyl-D-aspartate receptors in the central nervous system. Additionally, magnesium is known to have an anti-inflammatory effect. Inflammatory state may accompany with pain via peripheral or central sensitization. Recently, we reported that magnesium sulfate effectively attenuates not only postoperative pain but also increased pain intensity without serious adverse effects in the bilateral staged total knee arthroplasty. However, the exact mechanism regarding these effects of magnesium sulfate remains unclear. In the present study, we will investigate the analgesic mechanism of magnesium sulfate via analysis of endocrine neurosteroid levels in patients undergoing bilateral staged total knee arthroplasty.

NCT ID: NCT04349423 Completed - Depression Clinical Trials

Daily Assessment of Mood and Social Media Behaviors Study

Start date: February 1, 2020
Phase: N/A
Study type: Interventional

The purpose of this research study is to learn more about social media usage and its relation to emotions, biology, and mental health. Participants will complete daily assessments (5 times a day) over the course of 11 days in which they will report on their social media use, behaviors, and mood. During the first 4 days participants will be asked to continue using social media as typical. In the second half (7 days) participants will be randomized to social media usage groups (0 minutes, 30 minutes, 1 hour, 2 hour, 3 hours). There will be mental health and well-being measures provided at the beginning and end of the study. Lastly, to better understand how social media usage effects underlying mechanisms of stress, participants will be asked to provide saliva samples for 3 nights (pre, mid, and post) to assess for basal cortisol levels.

NCT ID: NCT03830762 Completed - Clinical trials for Peripheral Neuropathy

Xanamemâ„¢ in Healthy Elderly Subjects

XanaHES
Start date: January 21, 2019
Phase: Phase 1
Study type: Interventional

Xanamemâ„¢ is being developed as a potential drug for Alzheimer's disease. This study drug has been designed to change the cortisol levels in the brain. Cortisol is a naturally occurring hormone in the body. It is believed that reducing the level of cortisol will be a benefit in the treatment of Alzheimer's disease. The XanaHES study is testing the safety and tolerability of Xanamem. It is planned to enrol approximately 84 participants, male and female aged from 50 to 75 who are in good health, in the study at 1 centre in Australia. The XanaHES Phase I study is a single-blind study. Subjects will be randomised to receive either 20mg once daily Xanamem or Placebo in cohort 1. Once all subjects have completed the study treatment of 12 weeks, a dose escalation committee will decide if a new cohort, cohort 2, with 30mg once daily vs placebo is started.

NCT ID: NCT03759509 Completed - Fatigue Clinical Trials

Effects of Aerobic Exercise Training on Nurses' Sleep Quality, Fatigue, Attention and Cortisol Profile

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

Shift work in nursing has been found to result in sleep disruption and sleep deprivation, and in sleepiness or fatigue at work. Slow reaction, insufficient attention and poor judgement often come with increased fatigue, which contributes to a high risk of accident and patient safety. Studies have shown that aerobic exercise is helpful in promoting high sleep quality. The study is conducted a prospective parallel randomized trial is performed to 60 nurses with low sleep quality. The subjects are randomly assigned to: (i) the experimental group, in which aerobic exercise training is given; (ii) the control group, in which the subjects kept their original lifestyles. The study aims to investigate the effects of aerobic exercise training on nurses' sleep quality, fatigue, attention and cortisol profile.

NCT ID: NCT03554694 Recruiting - Anxiety Clinical Trials

Gut-brain Axis, Brain Function, and Behaviour.

Start date: May 6, 2018
Phase: N/A
Study type: Interventional

The aim is to test if dietary supplementation with prebiotics reduces measures of anxiety in healthy human participants with high self-reported levels of anxiety. Study will test for an effect on behavioural, neuroendocrine and brain imaging markers of anxiety.

NCT ID: NCT03530943 Recruiting - Clinical trials for Anxiety Disorders and Symptoms

Pet Partners for Promotion of Academic Life Skills

Pet PALS
Start date: August 2016
Phase: N/A
Study type: Interventional

The current study utilized a randomized controlled trial, conducted in a real-life setting, to determine whether, how, under which conditions, and for whom, infusing various levels of human-animal interaction (HAI) in a 4-week, university-based stress prevention program provides an effective approach to prevent negative ramifications of university students stress, promote student executive functioning and learning, while safeguarding animal welfare. This study will examine effects of sole exposure to evidence-based stress prevention content, hands-on HAI with registered PET Partner teams, or combinations thereof on students' moment-to-moment well-being and longer-term functioning in socioemotional, cognitive and physiological domains.This study will also develop a comprehensive coding system and measure the dynamic nature of behavior of participants, handlers and animals during university- based animal assisted activities, as well as the HAI environment. The data and analyses will then be utilized to inform the development of a quantitative measure to capture of the quality of human animal interaction in various settings to experimentally determine causal pathways underlying program effects on humans and animals.