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Coronary Microvascular Disease clinical trials

View clinical trials related to Coronary Microvascular Disease.

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NCT ID: NCT06212466 Not yet recruiting - Myocardial Ischemia Clinical Trials

MCG as a Noninvasive Diagnostic Strategy for Suspected INOCA (MICRO2)

MICRO2
Start date: June 3, 2024
Phase:
Study type: Observational

A prospective, multicenter, observational, single-arm trial to validate CardioFlux MCG's ability to diagnose myocardial ischemia caused by coronary microvascular dysfunction in patients with suspected ischemia and confirmed no obstructive coronary artery disease (suspected INOCA) by using diagnostic measures of coronary flow reserve (CFR) via invasive angiography as a reference standard for diagnosis.

NCT ID: NCT06139094 Completed - Clinical trials for Ischemic Heart Disease

MCG for Suspected INOCA Confirmed by Thermodilution-Derived CFR

MICRO(T)
Start date: December 20, 2023
Phase:
Study type: Observational [Patient Registry]

This study will be an observational registry to investigate the ability of magnetocardiography (MCG) in determining the presence of myocardial ischemia with the absence of obstructive coronary artery disease, by using an invasive reference standard coronary flow reserve (CFR) measured using thermodilution for diagnosis. The device is a magnetocardiography (MCG) scanner named CardioFlux, which is paired with cloud processing software. A CardioFlux scan appointment shall last approximately 15 minutes in duration and include a patient questionnaire following the scan.

NCT ID: NCT06125392 Recruiting - Clinical trials for Coronary Microvascular Disease

Multicenter Registry on Microvascular Dysfunction - Searching a New Ach Spasm Definition

MICRO-SNAPE
Start date: September 30, 2023
Phase:
Study type: Observational [Patient Registry]

The MICRO-SNAPE registry will collect data from patients undergoing investigation of microvascular dysfunction and coronary spasm in Europe and North America.

NCT ID: NCT05913999 Enrolling by invitation - Cancer Clinical Trials

Serial PET MPI in Patients Undergoing Cancer Treatment

Start date: June 1, 2023
Phase:
Study type: Observational

This study aims to evaluate the effects of cardiotoxic cancer therapies on myocardial blood flow (MBF) and perfusion in a prospective sample of VA patients.

NCT ID: NCT05841199 Recruiting - Clinical trials for Coronary Artery Disease

Coronary Flow During Rapid Heart Rates

VT flow
Start date: August 1, 2023
Phase:
Study type: Observational

The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1. What impact does coronary artery disease have on the ability for a patient to tolerate VT? 2. Does treatment of coronary artery disease with stents improve the tolerability of VT? Participants who are undergoing a clinically indicated coronary angiogram or coronary angioplasty procedure will have measurements of blood pressure, coronary pressure and coronary flow made during pacing at a range of heart rates.

NCT ID: NCT05825339 Recruiting - Angina, Stable Clinical Trials

Absolute Flow for Ischemia With No Obstructive Coronary Arteries

AF-INOCA
Start date: May 1, 2021
Phase:
Study type: Observational

The main objective is to prospectively validate the capacity of continuous thermodilution coronary flow reserve (CFRflow) as a predictor of the presence of angina measured by SAQ7 in patients with INOCA at 3 months. Secondary objectives include identifying hemodynamic factors related to the persistence of angina at 3 and 12 months, identifying clinical factors associated with the persistence of angina, establishing the prevalence of patients with coronary microvascular dysfunction within the cohort of INOCA patients, identifying predictors of major cardiovascular events at 12 months, validating the pathological value of MMR and establishing the pathological value of AF measured in ml/min. The study also aims to evaluate the concordance between measures of the coronary microvascular function obtained by continuous thermodilution and bolus thermodilution, as well as their concordance with clinical characteristics.

NCT ID: NCT05810051 Recruiting - Clinical trials for Coronary Microvascular Disease

Exercise and Coronary Microvascular Disease

ExerciseCMD
Start date: July 31, 2023
Phase: N/A
Study type: Interventional

Exercise CMD is a prospective single-center, open-label, parallel arms randomized controlled trial. This trial aims to assess the impact of cardiac rehabilitation on top of optimal medical therapy on patient-reported outcomes in subjects with coronary microvascular disease and non-obstructive coronary artery disease. Patients will undergo a microvascular assessment using bolus thermodilution techniques and those with criteria for microvascular angina (IMR ≥ 25) will be invited to participate. Patients will be randomized in a 1:1 ratio to either optimal medical therapy (OMT) or OMT plus a program of cardiac rehabilitations (CR). After randomization, spiro-ergometry and a SAQ-19 will be performed in all patients. Medical therapy will be standardized in both arms and the CR group will follow 36 sessions of the personalized physical training program of cardiac rehabilitation. Approximately 204 subjects (102 in each group) will be included at one site (OLV Aalst, Belgium). Clinical Follow-Up will be planned at 4 months. Patients with CCTA performed in standard of care will be invited for control CCTA 6 +/- 1 month after the invasive procedure.

NCT ID: NCT05805462 Recruiting - Clinical trials for Coronary Microvascular Disease

The Euro-CRAFT Registry

Euro-CRAFT
Start date: September 22, 2022
Phase:
Study type: Observational

The Euro-CRAFT Registry is a prospective, multicentric, international registry of patients undergoing functional assessment of the coronary microcirculation using the continuous thermodilution technique. Angina and quality of life questionnaires (Seattle Angina Questionnaire 19 - SAQ19, ORBITA app) will be obtained at baseline, at 6 months, and 1-year follow-up. Clinical follow-up will be performed at 1 year (optionally until 5 years).

NCT ID: NCT05793567 Not yet recruiting - Clinical trials for Myocardial Infarction

A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)

Start date: November 2024
Phase:
Study type: Observational

The purpose of this research is to find out if patients with Type 2 Myocardial Infarction (T2MI) without significant epicardial coronary artery disease (CAD) have a greater chance of having coronary microvascular disease (CMD).

NCT ID: NCT05743140 Recruiting - Clinical trials for Coronary Microvascular Disease

A Clinical Study of Fundus OCTA for the Identification of CMD

Start date: March 1, 2023
Phase:
Study type: Observational

Coronary microvascular dysfunction (CMD) carries an increased risk of adverse cardiovascular clinical outcomes. The association between fundus microcirculation changes and coronary microcirculation is not well understood. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) is a new type of optical diagnostic imaging technology for non-invasive detection, which can perform multi-dimensional quantitative assessment of fundus microcirculation. In this study, investigators intend to use the coronary angiography-derived index of microvascular resistance (caIMR) to screen patients with CMD, explore the relationship between relevant parameters based on OCT and OCTA measurements and caIMR, and evaluate the feasibility and clinical value of non-invasive identification of CMD through fundus OCT and OCTA.