Coronary Atherosclerosis Clinical Trial
Official title:
The Role of Adipokines Secreted by Epicardial Adipose Tissue in the Atherosclerosis of Coronary Arteries
The aim of the study is to investigate whether the expression and production of adipokines secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis.
Status | Recruiting |
Enrollment | 160 |
Est. completion date | January 22, 2018 |
Est. primary completion date | January 15, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: 1) Individuals undergoing cardiac surgery Exclusion Criteria: - Age < 18 years - HbA1c > 7.0% - Any change of antidiabetic medication the previous 3 months before the surgery - GFR < 60 mL/min/1.73 m2 - Liver disease - Cancer - Non-treated hyperthyroidism or hypothyroidism - Autoimmune disease - Infection - Any change in body weight at least 5% the previous 3 months before surgery - Significant dehydration. - Taking any of the following drugs the previous 3 months before surgery: hormones, antiobesity drugs |
Country | Name | City | State |
---|---|---|---|
Greece | University Hospital of Ioannina | Ioánnina |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Ioannina |
Greece,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Association between coronary artery disease and epicardial adipokines | Comparison of the mRNA and protein production of four adipokines [adiponectin, omentin-1, resistin, retinol binding protein-4(RBP4)] from the epicardial adipose tissue between the territories that are supplied by LAD and RCA. This comparison will be performed in the following clusters of groups: Cluster 1: NonDM-0 and DM-0 (comparison between territories that are supplied by non-stenosed coronary arteries) Cluster 2: NonDM-LR and DM-LR (comparison between territories that are supplied by stenosed coronary arteries) Cluster 3: NonDM-L, NonDM-R, DM-L and DM-R (comparison between a territory that is supplied by stenosed coronary artery and another territory that is supplied by non-stenosed coronary artery) |
Baseline measurement | |
Secondary | Impact of diabetes on epicardial adipokines | Comparison of the mRNA and protein production of four adipokines (adiponectin, omentin-1, resistin, RBP4) from the epicardial adipose tissue of the territory that is supplied by LAD or RCA between the following groups: NonDM-0 vs DM-0 NonDM-L vs DM-L NonDM-R vs DM-R NonDM-LR vs DM-LR |
Baseline measurement |
Status | Clinical Trial | Phase | |
---|---|---|---|
Withdrawn |
NCT02265146 -
ORACLE-NIRS: Lipid cORe Plaque Association With CLinical Events: a Near-InfraRed Spectroscopy Study
|
||
Completed |
NCT02335086 -
DNA Damage & Repair Proteins In Patients With Atherosclerotic Coronary Artery Disease
|
N/A | |
Completed |
NCT00811772 -
Trial of Drug Eluting Stent Versus Bare Metal Stent to Treat Coronary Artery Stenosis
|
N/A | |
Completed |
NCT02305953 -
Cytokines and Vascular Inflammation in Psoriasis
|
N/A | |
Completed |
NCT01642173 -
Assessment of Coronary Plaque Composition Using Optical Coherence Tomography
|
Phase 1 | |
Completed |
NCT02316782 -
Bifurcation Lesion Analysis and STenting / BLAST
|
||
Completed |
NCT00548613 -
Combination Stem Cell (MESENDO) Therapy for Utilization and Rescue of Infarcted Myocardium
|
Phase 1 | |
Terminated |
NCT00243308 -
Serp-1 for the Treatment of Acute Coronary Syndrome
|
Phase 2 | |
Recruiting |
NCT05105750 -
A Comparative Study of Indobufen and Aspirin in Patients With Coronary Atherosclerosis
|
Phase 4 | |
Completed |
NCT01722214 -
Trial on the Effect of Adalimumab on Vascular Inflammation in Patients With Psoriasis
|
Phase 4 | |
Terminated |
NCT01030328 -
AFRICA: Atorvastatin Plus Fenofibric Acid (TriLipix) in the Reduction of Intermediate Coronary Atherosclerosis
|
Phase 3 | |
Suspended |
NCT00790764 -
Phase II Combination Stem Cell Therapy for the Treatment of Severe Coronary Ischemia(CI)
|
Phase 2 | |
Active, not recruiting |
NCT01061398 -
CT-FIRST: Cardiac Computed Tomography Versus Stress Imaging For Initial Risk STratification
|
N/A | |
Completed |
NCT00431977 -
Validation Study of Coronary CT Angiography as a Screening Tool in Asymptomatic Diabetes
|
N/A | |
Completed |
NCT00431717 -
Coronary Computed Tomography Angiography and SPECT in Asymptomatic Diabetes
|
N/A | |
Recruiting |
NCT00155350 -
Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients
|
Phase 4 | |
Recruiting |
NCT05708547 -
Role of Mitophagy in Myeloid Cells During Coronary Atherosclerosis.
|
||
Terminated |
NCT02440646 -
Natural History of Coronary Atherosclerosis in Real-World Stable Chest Pain Patients Underwent Computed Tomography Angiography in Comparison With Invasive Multimodality Imaging
|
||
Terminated |
NCT01268319 -
CANARY: Coronary Assessment by Near-infrared of Atherosclerotic Rupture-prone Yellow
|
N/A | |
Completed |
NCT02576704 -
Prognostic Value of Myocardial Perfusion Heterogeneity in Normal SPECT Studies
|
N/A |