Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT06198673 |
| Other study ID # |
2023/D/18122023 |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
January 1, 2024 |
| Est. completion date |
December 31, 2026 |
Study information
| Verified date |
December 2023 |
| Source |
University of Roma La Sapienza |
| Contact |
Francesco Pelliccia, MD |
| Phone |
+394997 |
| Email |
f.pelliccia[@]mclink.it |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational [Patient Registry]
|
Clinical Trial Summary
In patients with chronic coronary syndrome (CCS), clopidogrel has a class I/A indication in
patients undergoing elective percutaneous coronary intervention (PCI). Although unproven, the
possibility exists that clopidogrel does not yield an optimal platelet inhibition in multiple
real-world scenarios that challenge current recommendations.
The aim of this prospective observational study io assess in a consecutive unselected series
of patients with CCS undergoing elective PCI the frequency of the following real world
clinical scenarios:
- No pretreatment at time of PCI ('naïve')
- Evidence of incomplete responsiveness to clopidogrel
- Indication to a complex PCI.
We expect to demonstrate:
- A not negligible proportion of patients with CCS are 'naïve' at time of elective PCI in
clinical practice and require a rapid onset of P2Y12 inhibition.
- A substantial proportion of patients with CCS who are treated with clopidogrel prior to
elective PCI have high platelet responsiveness at time of the procedure.
- A complex PCI is performed in a substantial proportion of patients with CCS.
Description:
In patients with chronic coronary syndrome (CCS), clopidogrel has a class I/A indication in
patients undergoing elective percutaneous coronary intervention (PCI) (Figure 1). Initiation
of oral P2Y12 inhibitors is usually delayed until the coronary anatomy is defined (Knuuti,
Levine). Clopidogrel (administered as a 600 mg loading dose followed by a 75 mg maintenance
dose) is the P2Y12 inhibitor of choice in CCS patients undergoing PCI (Knuuti, Levine). Also,
pre-treatment with clopidogrel is currently recommended if the probability of PCI is high (II
B/C). Although unproven, the possibility exists that clopidogrel does not yield an optimal
platelet inhibition in multiple real-world scenarios that challenge current recommendations,
as follows:
- P2Y12 inhibitors 'naive' patients with CCS who have an indication to PCI after coronary
angiography might experience deferral of PCI because they are not pre-treated with
clopidogrel (Selvarajah, 2021)
- Heterogeneity in individual response profiles to clopidogrel, with a considerable number
of patients yielding inadequate platelet inhibitory effects, might result in increased
risk of thrombotic events post-PCI (Galli). Individual responsiveness to P2Y12
inhibitors can be assessed through platelet function testing (Franchi), but its
implementation in clinical practice is currently not recommended. As a consequence, a
significant proportion of CCS patients are not on a fully effective dual antiplatelet
therapy (DAPT) at time of PCI.
- Complex PCIs are increasingly performed in CCS patients. Complex PCI is commonly defined
by any of the following characteristics: ≥ 3 drug eluting stents implanted, bifurcation
PCI with 2 stents, left main coronary artery PCI, saphenous vein graft PCI, total stent
length > 60 mm, or chronic total occlusion as target lesion (Figure 2). Importantly,
patients who undergo complex PCI have a substantially higher ischemic risk with
increased procedural complexity (Giustino, Genereaux). Preliminary observations suggest
that an intensive periprocedural platelet inhibition, even on top of DAPT pretreatment,
might be of benefit in stable patients undergoing percutaneous revascularization of
complex lesions (Marchese).
To assess in a consecutive unselected series of patients with CCS undergoing elective PCI the
frequency of the following real world clinical scenarios:
- No pretreatment at time of PCI ('naïve')
- Evidence of incomplete responsiveness to clopidogrel
- Indication to a complex PCI Consecutive patients with CCS undergoing elective PCI.
Patients will be grouped as follows:
- Pre-treatment with clopidogrel before elective PCI
- Patients receiving a clopidogrel loading at time of elective PCI in the cath lab
Patients receiving cangrelor during PCI in the cath lab and then receiving a P2Y12
inhibitor afterwards
- Patients with CCS undergoing elective PCI
- Patients' written informed and privacy consent obtained before the PCI procedure
- Male or female patients 18 to 80 years old
- Assessment of response to anti-platelet agents by VerifyNowTM
- Patients with active bleeding
- Patients with hypersensitivity to any anti-platelet agents or to any of its excipients
- Known pregnancy or breast-feeding female patients > 1,000 patients Multicenter
evaluation
- Pre-treatment with clopidogrel before elective PCI
- Patients receiving a clopidogrel loading at time of elective PCI in the cath lab
- Patients receiving cangrelor during PCI in the cath lab and then receiving a P2Y12
inhibitor afterwards
1-year
1. Frequency of 'naive' patients with CCS undergoing elective PCI
2. Frequency of complex coronary intervention in patients undergoing elective PCI
- Frequency of incomplete response to clopidogrel prior to elective PCI (as assessed by
VerifyNow TM)
- Frequency of the use of periprocedural i.v. cangrelor
- Frequency of the use of glycoprotein IIb/IIIa (GPIIb/IIIa) inhibitors
- Frequency of the use of clopidogrel, ticagrelor or prasugrel loading dose
- Mode of administration of oral P2Y12 inhibitors (crushed)
- Incidence of post-PCI ischemic complications
- Incidence of any post-PCI bleeding according to the Bleeding Academic Research
Consortium [BARC] criteria
- Incidence of major adverse cardiac events (MACE) - MACE will comprise any of the
following events: death, myocardial infarction (MI), ischemia-driven revascularisation
(IDR) and stent thrombosis (ST)
- Enrolment phase (1 year)
- Follow-up: 1-year
The study will be conducted in accordance with the Declaration of Helsinki on ethical
principles for medical research involving human subjects.
Informed consent to be included in this survey is mandatory for collecting individual data
and must be obtained from all subjects and/or their legal representative(s) as per local
regulations.
We expect to demonstrate:
- A not negligible proportion of patients with CCS are 'naïve' at time of elective PCI in
clinical practice and require a rapid onset of P2Y12 inhibition.
- A substantial proportion of patients with CCS who are treated with clopidogrel prior to
elective PCI have high platelet responsiveness at time of the procedure.
- A complex PCI is performed in a substantial proportion of patients with CCS.
