Total Body Perfusion in Patients With Chest Pain

Coronary Artery Disease Clinical Trial

— KOVERI  

Official title:

Total Body Perfusion in Patients With Chest Pain

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05825859
• Other study ID #: KOVERI
• Status: Recruiting
• Start date: April 11, 2023
• Est. completion date: August 2025

Study information

• Verified date: April 2023
• Source: Turku University Hospital
• Contact: Juhani Knuuti, MD
• Phone: +358500592998
• Email: juhani.knuuti[@]tyks.fi
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The Purpose of this study is to better understand changes in obstructive coronary artery disease in different organs other than the heart such as the brain and the kidneys using a new generation total body PET scanner.

Description:

Patients with chest pain and suspected CAD will be studied using total body PET imaging with O15-water perfusion imaging

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 300
• Est. completion date: August 2025
• Est. primary completion date: August 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Documented history of chest pain with CT imaging showing a potential for obstructive coronary artery disease

• Ability to sustain adenosine injection 0.14 mg/kg/min

Exclusion Criteria:

• Second or third degree AV-block without pacemaker

• Sick sinus syndrome

• Consumption of coffee or aminophylline within 12 hours of administration

• Recent use of dipyridmole or dipyridamole-containing medications

• Known hypersensitivity to adenosine

• Unstable acute MI or acute coronary artery syndrome, and prior cardiac transplantation

• Active wheezing and bronchospasm

• Sinus bradycardia with HR<40 bmp

Related Conditions & MeSH terms

• Chest Pain
• Coronary Artery Disease

Locations

Country	Name	City	State
Finland	Turku University Hospital	Turku

Sponsors (1)

Lead Sponsor	Collaborator
Turku University Hospital

Country where clinical trial is conducted

Finland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Perfusion in heart, brain and kidneys during rest and adenosine stress, and their associations with psychologic factors and anginal symptoms	Multiorgan perfusion changes in patients with chest pain	The imaging day
Secondary	The association between perfusion in heart, brain and kidneys, and adverse events during five year follow-up	Multiorgan perfusion changes in patients with chest pain as related to outcome	Five year follow-up after the imaging