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NCT05825859 Clinical Trial

Total Body Perfusion in Patients With Chest Pain

Coronary Artery Disease Clinical Trial

— KOVERI  

Official title:
Total Body Perfusion in Patients With Chest Pain

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05825859
Other study ID # KOVERI
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date April 11, 2023
Est. completion date August 2025

Study information
Verified date April 2023
Source Turku University Hospital
Contact Juhani Knuuti, MD
Phone +358500592998
Email juhani.knuuti@tyks.fi
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The Purpose of this study is to better understand changes in obstructive coronary artery disease in different organs other than the heart such as the brain and the kidneys using a new generation total body PET scanner.

Description:

Patients with chest pain and suspected CAD will be studied using total body PET imaging with O15-water perfusion imaging

Recruitment information / eligibility
Status Recruiting
Enrollment 300
Est. completion date August 2025
Est. primary completion date August 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Documented history of chest pain with CT imaging showing a potential for obstructive coronary artery disease - Ability to sustain adenosine injection 0.14 mg/kg/min Exclusion Criteria: - Second or third degree AV-block without pacemaker - Sick sinus syndrome - Consumption of coffee or aminophylline within 12 hours of administration - Recent use of dipyridmole or dipyridamole-containing medications - Known hypersensitivity to adenosine - Unstable acute MI or acute coronary artery syndrome, and prior cardiac transplantation - Active wheezing and bronchospasm - Sinus bradycardia with HR<40 bmp

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Finland Turku University Hospital Turku

Sponsors (1)
Lead Sponsor Collaborator
Turku University Hospital

Country where clinical trial is conducted

Finland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Perfusion in heart, brain and kidneys during rest and adenosine stress, and their associations with psychologic factors and anginal symptoms Multiorgan perfusion changes in patients with chest pain The imaging day
Secondary The association between perfusion in heart, brain and kidneys, and adverse events during five year follow-up Multiorgan perfusion changes in patients with chest pain as related to outcome Five year follow-up after the imaging
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