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Clinical Trial Summary

Hybrid coronary revascularization (HCR), a combination of coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI), has emerged as an alternative treatment for multivessel coronary artery disease patients. However, the ideal sequence (PCI or CABG) is unclear. Therefore, the aim of this non-inferiority randomized controlled trial is to investigate the ideal sequence of hybrid coronary revascularization with endoscopic coronary revascularization.


Clinical Trial Description

When two or more vessels are occluded in coronary artery disease, the optimal revascularization strategy remains uncertain. Hybrid coronary revascularization (HCR), a combination of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI), has emerged as an alternative treatment for multivessel coronary artery disease patients. The standard procedures, CABG or PCI alone, could have some limitations. A heavily calcified proximal aorta or a poor target vessel could be a problem for CABG. Simultaneously, the left anterior descending (LAD) coronary artery could be unfavorable for PCI due to excessive vessel tortuosity or chronic total occlusion. In HCR, the advantages of both PCI and totally endoscopic CABG (endo-CABG) are combined. The use of the left internal mammary artery (LIMA) and right internal mammary artery (RIMA) for bypassing the LAD and PCI for non-LAD coronary lesions could be a feasible alternative. A meta-analysis of more than 1100 patients states that hybrid revascularisation outcomes are similar to CABG alone.However, all these studies used a mini-sternotomy or thoracotomy during the surgery. The use of totally endoscopic procedures could improve the outcomes after hybrid revascularization. Secondly, the ideal sequence (PCI or CABG) is unclear. Therefore, the aim of this non-inferiority randomized controlled trial is to investigate the ideal sequence of hybrid coronary revascularization with endoscopic coronary revascularization. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05184075
Study type Interventional
Source Jessa Hospital
Contact Abdullah Kaya, PhD
Phone 011 33 71 05
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date January 12, 2022
Completion date July 1, 2023

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