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Clinical Trial Summary

This study will investigate the role of polygenic risk scores (PRS) in preventive health.


Clinical Trial Description

This study will investigate the role of polygenic risk scores (PRS) in preventive health. Specifically, the purpose of this study is to determine whether knowledge of the degree of coronary artery disease (CAD) genetic risk or glaucoma genetic risk, as measured and conveyed by a PRS, influences patient and physician decision-making as well as clinical outcomes during short-term (6-month / 2-year) and long-term (3-year / 5-year) follow-up. A CAD and glaucoma PRS will be calculated for all study participants, with participants randomized to receiving either their CAD or glaucoma PRS. This study design allows for causal attribution of preventive actions and clinical outcomes to the receipt and degree of genetic risk. The design is informed by a pilot (MyGeneRank) and phase 1 (PEPRS first phase) study, with the key extensions being the addition of randomization and increasing the study population size to power causal association with long-term, hard clinical outcomes. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05175651
Study type Interventional
Source Scripps Translational Science Institute
Contact Ali Torkamani, PhD
Phone 858-784-2082
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date January 15, 2022
Completion date January 15, 2027

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