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Quercetin in Coronary Artery By-pass Surgery — Q-CABG  

Coronary Artery Disease Clinical Trial

Official title:
Étude randomisée contrôlée Par Placebo de Phase II Visant à Mesurer l'Effet Anti-inflammatoire et Anti-sénescence de la quercétine Lors d'Une Chirurgie Cardiaque

Clinical Trial Summary

The purpose of this study is to test the anti-inflammatory and anti-senescence effects of quercetin during coronary artery by-pass graft surgery.

Clinical Trial Description

After being informed about the study and the potential risk, all patients giving written informed consent will be randomized in a double-blind manner (participant and investigators) on 1:1 ratio to receive quercetin (500 mg twice daily) or placebo (twice daily) starting 2 days before a coronary artery by-pass graft surgery and for the duration of their hospitalization but up to 10 days (i.e. up to 7 days post-surgery). Blood (5 ml) will be collected the first morning after recruitment (t-1), 24h post-surgery (t1), day 4 post-surgery (t2) and day of hospital discharge for blood analyses. During the surgery, if a discarded segment of mammary artery is available, it will be collected for laboratory work. Health status will be assessed during the follow-up visit 8 to 12 weeks post-surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04907253
Study type Interventional
Source Montreal Heart Institute
Contact
Status Active, not recruiting
Phase Phase 2
Start date June 4, 2021
Completion date October 1, 2024
View Details
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