Coronary Computed Tomographic Angiography in Intermediate-risk Chest Pain Patients — FAST-CCTA  

Coronary Artery Disease Clinical Trial

Official title: Randomized Evaluation of Coronary Computed Tomographic Angiography in Intermediate-risk Patients Presenting to the Emergency Department With Chest Pain

Status Recruiting

Clinical Trial Summary

The aim is to determine whether a diagnostic strategy including early coronary computed tomographic angiography in intermediate-risk patients presenting to the Emergency Department with chest pain reduces the composite endpoint of death, readmission because of myocardial infarction or unstable angina requiring revascularization.

Clinical Trial Description

Patients presenting to the ED with chest pain or other symptoms suggestive of ACS, without acute MI but with an intermediate risk (HEART-score >3) will after written informed consent be randomized to either a strategy with an initial CCTA or not.

Patients randomized to strategy including early CCTA will receive standard care according to responsible physician and perform a CCTA as soon as possible (in most cases within 24 hours, but at least within 7 days).The result will be presented to the responsible physician who will plan further care of the patients.

Patients randomized to a strategy not including early CCTA will receive further care (including examinations) according to responsible physician but not include early CCTA. These patients will often undergo a non-invasive functional test, such as Exercise-ECG, stress echocardiography or nuclear imaging according to local routines, but not always.

All patients should receive optimal prevention according to current guidelines. The responsible physician will be encouraged to initiate secondary prevention measures if examinations show signs of CAD.

The primary endpoint is composite of death, readmission because of MI or unstable angina requiring revascularization at 3 years. ;

Related Conditions & MeSH terms

• Acute Coronary Syndrome
• Chest Pain
• Coronary Artery Disease

• NCT number: NCT04748237
• Study type: Interventional
• Source: Karolinska Institutet
• Contact: Liselotte Persson, RN
• Phone: +46812355000
• Email: Liselotte.Persson@sll.se
• Status: Recruiting
• Phase: N/A
• Start date: January 21, 2021
• Completion date: December 2025