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Multislice Computed Tomography Assessment of PCSK9 Inhibition on Coronary Perfusion — MARKOV  

Coronary Artery Disease Clinical Trial

Official title:
Multi-slice CT Scan Assessment of the Impact of PCSK9 Inhibition With Evolocumab on Coronary Perfusion in Patients With Reduced Coronary Fractional Flow Reserve (FFR).

Clinical Trial Summary

The MARKOV study is an investigator-sponsored single arm, prospective study to assess the effect of evolocumab on the improvement in coronary flow (FFRCT) after 18 and 36 months of treatment in patients with coronary atherosclerosis.

Clinical Trial Description

The MARKOV study is an investigator-initiated, open-label, single arm, international, multicenter, prospective study to assess the effect of evolocumab on the improvement in coronary flow (FFRCT) after 18 and 36 months of treatment in patients with coronary atherosclerosis. The study will be conducted in 5 sites in 3 different countries in Europe. Patients will receive evolocumab for approximately 3 year. The expected duration of the entire study from First Subject First Visit to Last Subject Last Follow-up is 46 months (3 year and 10 months). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03851263
Study type Interventional
Source ECRI bv
Contact
Status Withdrawn
Phase Phase 4
Start date August 30, 2019
Completion date February 24, 2023
View Details
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