Heart Valve Disease Clinical Trial
Official title:
Effects of Hyperoxia on Oxidative Stress in Patients Undergoing Open Heart Surgery
Patients undergoing Open Cardiac Surgery will be randomized into two groups. Group I will be
ventilated with 40% Fio2 during induction, surgery and in Postoperative care unit. Group II
will be ventilated with 100% Fio2 during induction and with 60-70% ( determined according to
the arterial blood gas sample results) during surgery and in Postoperative care unit.
Hemodynamic parameters ( systolic arterial pressure, diastolic arterial pressure, heart rate
), Arterial blood gas samples ( PaO2, PaCO2, pH, Oxygen saturation, Lactate), and pre and
post cardiopulmonary bypass Superoxide dismutase and malonyl aldehyde levels.
n/a
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Screening
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