Single Transpulmonary Thermodilution and Continuous Monitoring of Central Venous Oxygen Saturation During Off-pump Coronary Surgery

Coronary Artery Disease Clinical Trial

— OPCAB  

Official title:

Single Transpulmonary Thermodilution and Continuous Monitoring of Central Venous Oxygen Saturation During Off-pump Coronary Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00624494
• Other study ID #: 4347.07.2006
• Secondary ID: Grant 4347.07.20
• Status: Completed
• Phase: N/A
• Start date: May 2005
• Est. completion date: September 2008

Study information

• Verified date: March 2024
• Source: Northern State Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the present study was to evaluate the usefulness of an algorithm based on hemodynamic parameters obtained by single transpulmonary thermodilution (STD) combined with continuous monitoring of central venous oxygen saturation (ScvO2) for perioperative management of patients undergoing OPCAB.

Description:

At the present time, there is an increasing tendency to perform off-pump coronary artery bypass grafting (OPCAB). However, OPCAB poses a variety of challenges from the point of view of the anesthesiologist and the intensivist. The aim of the present study was to evaluate the usefulness of an algorithm based on hemodynamic parameters obtained by single transpulmonary thermodilution (STD) combined with continuous monitoring of central venous oxygen saturation (ScvO2) for perioperative management of patients undergoing OPCAB.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: September 2008
• Est. primary completion date: August 2008
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• Patients with coronary artery disease, ranked ASA II-III and scheduled for elective OPCAB

Exclusion Criteria:

• Age < 18 years
• Severe valve dysfunction or peripheral vascular disease
• Simultaneous interventions (carotid endarterectomy, aneurysm repair, etc.)
• Transfer to CPB during surgery

Related Conditions & MeSH terms

• Coronary Artery Disease
• Goal Directed Therapy
• Hemodynamic Monitoring

Intervention

Device:
• Conventional monitoring
In the CM group, therapy was guided by central venous pressure, mean arterial pressure (MAP) and heart rate (HR)
• Advanced monitoring
In the AM group by the intrathoracic blood volume index, MAP, HR, central venous oxygen saturation (ScvO2) and cardiac index (CI). The measurements were performed before and during surgery, and at 2, 4 and 6 hrs post-operatively.

Locations

Country	Name	City	State
Russian Federation	Dep. of Anesthesiology, Northern SMU	Arkhangelsk

Sponsors (2)

Lead Sponsor	Collaborator
Northern State Medical University	University of Tromso

Country where clinical trial is conducted

Russian Federation, 

References & Publications (1)

Smetkin AA, Kirov MY, Kuzkov VV, Lenkin AI, Eremeev AV, Slastilin VY, Borodin VV, Bjertnaes LJ. Single transpulmonary thermodilution and continuous monitoring of central venous oxygen saturation during off-pump coronary surgery. Acta Anaesthesiol Scand. 2 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	length of hospital stay	Length of the hospital stays, Days	one month