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Coronary Artery Calcification clinical trials

View clinical trials related to Coronary Artery Calcification.

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NCT ID: NCT06379295 Recruiting - Clinical trials for Coronary Artery Disease

Coronary Artery Calcification Assessed on PET Scanner (PET : Positron Emission Tomography)

CALCOTEP
Start date: May 21, 2024
Phase:
Study type: Observational

Calcification artery calcium (CAC) scoring is a valuable tool for determining the risk of major adverse cardiac events. It was found that CAC can be quantitatively assessed, by manual scoring or using deep-learning, on low-dose non electrocardiogram-gated, contrast-enhanced or non-enhanced computed tomography (CT-scan) performed in association of PET acquisition, with a good agreement with standard scans. The purpose of this study is to determine the impact of a systematic coronary artery calcification evaluation in patients undergoing flourine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging to improve primary prevention of cardiovascular diseases. A visual calcification artery calcium assessment will be made for each patient, dividing them into four groups: none, mild, moderate or heavy calcification artery calcium. When possible, a calcification artery calcium score will be computed. Each patient will complete a questionnaire to collect risk factors, history of cardiovascular diseases and medications.

NCT ID: NCT06301009 Not yet recruiting - Clinical trials for Cardiovascular Diseases

The AI-CAC Model for Subclinical Atherosclerosis Detection on Chest X-ray

AI-CAC-PVS
Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The AI-CAC model is an artificial intelligence system capable of assessing the presence of subclinical atherosclerosis on a simple chest radiograph. The present study will provide prospective validation of its diagnostic performance in a primary prevention population with a clinical indication for coronary artery calcium (CAC) testing.

NCT ID: NCT06276114 Completed - Clinical trials for Coronary Artery Calcification

IVL vs ELCA for Stent Underexpantsion (IVL-ELCA DRAGON)

DRAGON
Start date: August 1, 2020
Phase:
Study type: Observational [Patient Registry]

The IVL- ELCA DRAGON Registry is a multicenter study that enrolled consecutive patients with stent underexpansion treated with IVL ora ELCA in high-volume PCI centers. The primary efficacy endpoint was device success (technical success with a final stent expansion ≥ 80%). Thirty days device-oriented composite endpoint (DOCE: cardiac death, target lesion revascularization, or target vessel myocardial infarction) was the secondary endpoint.

NCT ID: NCT06181240 Recruiting - Clinical trials for Coronary Artery Disease

Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)

FRACTURE
Start date: November 17, 2023
Phase: N/A
Study type: Interventional

The FRACTURE Trial is a prospective, non-randomized, single-arm, multicenter, interventional study in US and international centers.

NCT ID: NCT06075602 Recruiting - Clinical trials for Coronary Artery Disease

COMPLEX Registry - A Prospective COhort Study to Describe the Management and Outcomes of Patients Presenting With compLEX and Calcified Coronary Artery Disease

COMPLEX
Start date: November 1, 2021
Phase:
Study type: Observational [Patient Registry]

The purpose of the COMPLEX Registry is to prospectively and retrospectively collect baseline, clinical and procedural data of patients who have undergone PCI or CABG for complex and/ or calcified chronic CAD, irrespective of clinical presentation as well as to prospectively collect data about their clinical outcomes. The outcomes will be compared in different clinical subgroups (e.g. PCI vs. CABG). The impact of current PCI techniques/ devices, but also CABG strategies in different clinical settings and coronary artery lesions on cardiovascular outcomes will be assessed.

NCT ID: NCT05973994 Recruiting - Clinical trials for Coronary Artery Calcification

Shockwave Induced Attenuation of Calcified Plaques Quantified With OCT

SCALPO
Start date: February 21, 2022
Phase:
Study type: Observational [Patient Registry]

The goal of this observational, prospective, multicenter study is to explore local action of coronary calcium fragmentation exerted by endovascular lithotripsy by images acquired with OCT, in patients with coronary artery calcifications responsible for significant stenosis, candidate to PCI. The main question it aims to answer, is the ability of Shockwave System to reduce calcium density in the Region of Interest (ROI) of the vessel wall.

NCT ID: NCT05858879 Not yet recruiting - Clinical trials for Coronary Artery Calcification

Notification of Incidental Coronary Artery Calcium in Patients With Atherosclerotic Cardiovascular Disease (NOTIFY-ASCVD)

NOTIFY-ASCVD
Start date: July 2024
Phase: N/A
Study type: Interventional

Estimate the impact of notifying both patients and their clinicians of the presence of incidental coronary artery calcium (CAC) on initiation of lipid-lowering therapy in patients with ASCVD who are not receiving lipid-lowering therapy.

NCT ID: NCT05845424 Not yet recruiting - Metabolic Syndrome Clinical Trials

High-intensity Statin and Ezetimibe Therapy for Asymptomatic Patients With Positive Coronary Calcium

DECISION-CAL
Start date: June 1, 2023
Phase: Phase 4
Study type: Interventional

The aim of this study is to compare safety and efficacy between the aggressive treatment with combination of high-intensity statin and ezetimibe and the current standard lipid lowering treatment in asymptomatic patients with presence of coronary calcification.

NCT ID: NCT05818098 Recruiting - Clinical trials for Coronary Artery Calcification

Coronary Intravascular Lithotripsy System in Patients With Coronary Artery Calcification (VIGOUR)

Start date: March 29, 2023
Phase: N/A
Study type: Interventional

This is a prospective and multicenter clinical investigation aiming to evaluate the safety and effectiveness of coronary intravascular lithotripsy system for the treatment of patients with coronary calcification.

NCT ID: NCT05588895 Enrolling by invitation - Clinical trials for Coronary Artery Calcification

Picture of Incidental Calcium To Understand Risk Estimate (PICTURE) Trial

PICTURE
Start date: January 8, 2024
Phase: N/A
Study type: Interventional

This is a prospective randomized controlled trial assessing the impact of notifying patients and their clinicians of an incidental finding of coronary artery calcification (CAC) indicating increased cardiovascular risk. Patients will be identified through completed radiology orders for non-gated, non-contrast chest CT in the appropriate clinical context and then will have an EHR screen for inclusion criteria. The presence of CAC will be confirmed by a board-certified physician. Eligible patients will be randomized to CAC notification or usual care using a 1:1 stratified block randomization method based on baseline statin use.