Coronary Arteriosclerosis Clinical Trial
Official title:
A Randomised Controlled Trial to Compare Angiographic Patency of Radial Artery Versus Saphenous Vein Used as Free Aorto-coronary Grafts in Coronary Revascularization
The purpose of this study is to determine whether the radial artery (artery in the arm) or saphenous vein (vein in the leg), when used as bypass grafts for coronary artery bypass surgery, have a greater patency rate (degree of opening)at 5 years after surgery.
Arteries differ from veins both in morphology and physiology. Thus the way they behave as in
vivo conduits when used in coronary artery bypass grafting is also likely to be different.
This may partly explain the predisposition of veins used as coronary conduits to accelerated
atherosclerosis in comparison with the internal mammary artery grafts. There are presently
few data describing the properties of the radial artery as an in-vivo coronary conduit over
the longer-term.
The study will compare angiographic patency of the radial artery or saphenous vein graft
anastomosed to the native left circumflex coronary territory at 3 months and 5 years after
surgery. A substudy will compare 5-year post-surgery diameter and blood flow of in-vivo
radial artery and saphenous vein grafts in response to endothelium-dependent and
non-endothelium-dependent stimuli when patients attend for their scheduled follow-up
angiogram.
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