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Corneal Endothelial Cell Loss clinical trials

View clinical trials related to Corneal Endothelial Cell Loss.

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NCT ID: NCT06396156 Completed - Clinical trials for Corneal Endothelial Cell Loss

Anterior Versus Posterior Artisan Intraocular Lens Fixation in Aphakic Children With Insufficient Capsular Support.

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

The Artisan lens (Artisan Aphakic, Ophtec BV) is an iris- claw lens designed for implantation in children with insufficient capsular support. In spite of less surgical manipulations and a relatively shorter operation time, the procedure carries the risk of corneal endothelial cell loss or dis-enclavation, particularly in children. However, most of the studies that studied iris-claw lenses in aphakic children were retrospective evaluated only a single technique; either anterior or retropupillary fixation, or comparable to other techniques of fixation. Thus the aim of this work is to prospectively compare the 2 techniques of iris-claw lens implantation and their effects on central endothelial cell density, the anatomical and visual outcome, as well as the complications' rate.

NCT ID: NCT05847387 Recruiting - Clinical trials for Corneal Endothelial Cell Loss

The Viability Control of Human Endothelial Cells Before Keratoplasty (V-CHECK) Study

V-CHECK
Start date: December 1, 2023
Phase:
Study type: Observational

The purpose of this international cohort study is to validate a new method for preoperative assessment of endothelial viability in donor corneal tissues for transplantation, and to correlate endothelial health as assessed by the surgical team to functional and structural long-term outcomes in the cohort of patients receiving them.

NCT ID: NCT05587205 Recruiting - Cataract Clinical Trials

Study to Assess Safety and Tolerability of EO2002

Start date: December 1, 2022
Phase: Phase 1
Study type: Interventional

The goal of this clinical study is to assess the safety of intracameral injection of EO2002 in subjects post-cataract surgery.

NCT ID: NCT05529485 Completed - Cataract Clinical Trials

Quantification of Factors Influencing Endothelial Damage During Phacoemulsification

PREDICSPILOT
Start date: January 12, 2022
Phase:
Study type: Observational

The aim of this study is to determine the principal factors that influence endothelial cell loss three month post cataract surgery. Methods: Multi center observational Cohort study, inclusion period from 12/01/2022 to 10/06/2022. One hundred and seventy-five eyes of hundred and four patients who have appointment for cataract surgical indication were included. The percentage of corneal endothelial cell loss was quantified using specular microscopy before and 3 months after the surgery. 14 variables (pre-operative and intra-operative) that could be associated to endothelial cell injury were selected. A bivariate analysis of relationship between these factors and endothelial cell loss at 3 months was performed by simple linear regression (Wilcoxon and Fischer tests). Multivariate analysis was performed by multiple linear regression in order to identify the factors independently related to endothelial cell loss.

NCT ID: NCT05522842 Not yet recruiting - Clinical trials for Corneal Endothelial Cell Loss

Corneal Endothelium in Diabetics Undergoing Phacoemulsification

Start date: November 1, 2023
Phase:
Study type: Observational

evaluate and compare the changes in corneal endothelial cell count density between diabetic and non diabetic patients undergoing phacoemulsification surgery, and to evaluate the effect of duration, and control of diabetes on corneal morphology.

NCT ID: NCT05447130 Completed - Clinical trials for Pseudoexfoliation Syndrome

Corneal Endothelium After Phacoemulsification in Pseudo Exfoliation Syndrome

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

To study corneal endothelial cells changes after phacoemulsification in patients with senile cataract and pseudoexfoliation syndrome (PEX) compared with control patients with senile cataract using specular microscope.

NCT ID: NCT05265832 Completed - Cataract Clinical Trials

Influencing Factors of the Corneal Endothelial Cell Loss

PREDICS
Start date: May 4, 2022
Phase: N/A
Study type: Interventional

This is a multi-center cohort study with prognostic aims to identify factors associated with endothelial cell loss during cataract surgery. Patients will have their endothelial density measured by specular microscopy preoperatively, at 1 month and at 3 months after surgery. The rest of their management will be in line with standard practice.

NCT ID: NCT05194891 Not yet recruiting - Clinical trials for Endothelial Cell Loss, Corneal

Endothelial Changes in Pseudoexfoliation Syndrome

PEX
Start date: February 1, 2022
Phase:
Study type: Observational

this study aimed to evaluate the corneal endothelial cell changes before and after phacoemulsification in pseudoexfoliative patients relative to healthy adults.

NCT ID: NCT05119270 Recruiting - Cataract Clinical Trials

Comparison of Phacoemulsification and Corneal Damage Between FLACS and Standard Phaco With Two Handpieces

Start date: December 1, 2021
Phase: N/A
Study type: Interventional

The main goal of this study is to compare traditional cataract surgery with two new technologies: the femtosecond laser and the new Active Sentry handpiece. The femtosecond laser is used in several fields of ophthalmology and allows to automate multiple key steps of cataract surgery. The new generation of handpiece called Active Sentry has the particularity to detect the pressure inside the eye in real time and to adjust it to avoid large variations. Theses technologies would potentially increase the efficacy and safety of standard cataract surgery. This study therefore aims at evaluating the differences in cumulative dissipated energy and endothelial cell loss between femtosecond laser assisted cataract surgery with the new Active Sentry handpiece compared to standard phaco with new (Active Sentry) or older handpieces (OZil).

NCT ID: NCT04547036 Completed - Glaucoma Clinical Trials

Changes in Corneal Endothelial Cell Density After Transscleral ab Interno Glaucoma Gel Stent Implantation

Start date: January 30, 2020
Phase:
Study type: Observational

The objective of this study is to evaluate the change of endothelial cell count after XEN45 in patients with or without cataract operation.