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Chronic Obstructive Pulmonary Disease clinical trials

View clinical trials related to Chronic Obstructive Pulmonary Disease.

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NCT ID: NCT01701934 Terminated - Clinical trials for Chronic Obstructive Pulmonary Disease

Impact of Roflumilast on Visceral Adiposity and Metabolic Profile in Chronic Obstructive Pulmonary Disease

RAMBO
Start date: February 2013
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether roflumilast can improve metabolic profile and reduce visceral adiposity in patients with chronic obstructive pulmonary disease (COPD).

NCT ID: NCT01697332 Terminated - Clinical trials for Chronic Obstructive Pulmonary Disease

Functional Applications of Hyperpolarized 129Xe MRI

Start date: January 2013
Phase: Phase 1/Phase 2
Study type: Interventional

The overall objectives of our study are to determine the capabilities of hyperpolarized 129Xe MRI to measure lung function and its potential to sensitively detect pulmonary disease and its progression in COPD. We hypothesize that measurement of alveolar surface area, septal thickness, and capillary transit time measured with hyperpolarized 129Xe will correlate better with quality of life measures in COPD subjects than traditional diagnostic measures such as spirometry and Computed Tomography.

NCT ID: NCT01612793 Terminated - Clinical trials for Chronic Obstructive Pulmonary Disease

Vagus Nerve Stimulation for Management of Bronchoconstriction in Patients Hospitalized With COPD Exacerbations

Start date: October 2012
Phase:
Study type: Observational

This study will look at the safety, improving symptoms and decreasing the length of stay of patients admitted to the hospital with COPD.

NCT ID: NCT01592656 Terminated - Clinical trials for Chronic Obstructive Pulmonary Disease

Long-term Effects of Non-invasive Ventilation in Hypercapnic Chronic Obstructive Pulmonary Disease (COPD) Patients

Start date: February 2011
Phase: Phase 2
Study type: Interventional

In this multicenter study the comparison of the mass flow distribution and redistribution versus the relative blood flow per lobe (as a surrogate for Ventilation/ Perfusion (V/Q) matching) with functional respiratory imaging (FRI) and arterial blood gas (ABG) values will be evaluated in hypercapnic Chronic Obstructive Pulmonary Disease (COPD) patients. Therefore a low dose Computed Tomography (CT) scan will be taken in a population of 30 patients with non-invasive ventilation (NIV) and in a control group of 10 patients without NIV. The CT-scan will be used for FRI.

NCT ID: NCT01584739 Terminated - COPD Clinical Trials

AZD8683 Multiple Dose Study in Healthy Volunteers and Chronic Obstructive Pulmonary Disease (COPD) Patients

Start date: June 2012
Phase: Phase 1
Study type: Interventional

This study will investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending inhaled doses of AZD8683 in Healthy volunteers and repeated inhalation of one dose level of AZD8683 in patients with chronic obstructive pulmonary disease given once daily.

NCT ID: NCT01554488 Terminated - Asthma Clinical Trials

Inhaled Fluticasone Effects on Upper Airway Patency in Obstructive Lung Disease

InFLOW
Start date: March 12, 2013
Phase: Phase 4
Study type: Interventional

The Chairman of the Veterans' Disability Benefits Commission reported at a recent US Senate hearing that asthma, chronic obstructive pulmonary disease (COPD), and sleep apnea are among the top 13 most frequent diagnoses leading to disability under the Department of Defense and the VA system statutes. Recent research finds that sleep apnea is more common among asthma and COPD individuals, and this may be caused by inhaled corticosteroid use. Many Veterans are currently using inhaled corticosteroids, and many more will be prescribed such medications, given their recent inclusion in international treatment guidelines. As such, this study addresses a critical need by researching the role of a potent inhaled corticosteroid in promoting sleep apnea, the determinants of this response, and the ways through which it occurs. Results from this study will form the foundation for future research aimed at expanding understanding of the effects of inhaled corticosteroids on the upper airway, as well as developing means to prevent or counteract them.

NCT ID: NCT01526642 Terminated - Clinical trials for Chronic Obstructive Pulmonary Disease

Home Non-invasive Ventilation for Chronic Obstructive Pulmonary Disease Patients

NIVOLD
Start date: December 2011
Phase: N/A
Study type: Interventional

Chronic Obstructive Pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure are more likely to develop exacerbations. Non-invasive ventilation has been proposed to treat acute respiratory failure but little information is available about the benefits of home non-invasive ventilation in COPD patients with chronic hypercapnic respiratory failure surviving an acute hypercapnic respiratory failure. The purpose of this study is to determine whether home non-invasive ventilation can reduce recurrent acute hypercapnic respiratory failure in COPD patients who survived an episode of acute hypoxemic respiratory failure (AHRF) treated by Non-invasive ventilation (NIV).

NCT ID: NCT01494896 Terminated - Clinical trials for Chronic Obstructive Pulmonary Disease

Impact of Inhaled Treprostinil Sodium on Ventilation Perfusion Matching

Start date: November 2011
Phase: N/A
Study type: Observational

The purpose of this study is to see how inhaled treprostinil sodium (Tyvaso) affects the amount of air and blood that reach the alveoli, or tiy air sacs, in the lungs of patients with Group 1 Pulmonary Arterial Hypertension with concomitant Chronic Obstructive Pulmonary Disease (COPD).

NCT ID: NCT01473758 Terminated - Clinical trials for Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation

Effect of Roflumilast at Acute Exacerbations of Chronic Obstructive Pulmonary Disease

TREAT
Start date: February 2012
Phase: Phase 2
Study type: Interventional

The purpose of this trial is to investigate if roflumilast can reduce the neutrophilic inflammation at acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD). In addition, the potential benefit of roflumilast on severity and recovery periods of acute COPD exacerbations will be assessed using patient diaries and questionnaires.

NCT ID: NCT01437878 Terminated - Clinical trials for Chronic Obstructive Pulmonary Disease

Effects of Ventavis in Patients With Pulmonary Hypertension (PH) Secondary to Chronic Obstructive Pulmonary Disease (COPD)

Start date: March 2012
Phase: Phase 2
Study type: Interventional

This is a phase 2, Multi-center, double-blind, randomized, placebo-controlled study to evaluate the effects of inhaled Iloprost in patients with pulmonary hypertension secondary to COPD. The main objective is to investigate the effect of iloprost on exercise endurance time during constant work rate cardiopulmonary exercise testing. Other efficacy and safety endpoints will additionally be analyzed.