Ivabradine in Patients With Congestive Heart Failure

Status Completed

Clinical Trial Summary

The aim of this study is to assess the efficacy of Ivabradine therapy in patients with congestive heart failure using the cardiac biomarkers NT-Pro BNP and Neopterin.

Clinical Trial Description

- Approval will be obtained from Research Ethics Committee of Faculty of Pharmacy, Damanhour University - All participants have agreed to take part in this clinical study and provide informed consent - A 3 months, prospective interventional study. - Sixty ambulatory, clinically stable symptomatic patients with systolic chronic HF (≥ 4 weeks), on optimized standard medical therapy were consecutively included and randomly allocated to the ivabradine group (n=30) and non-ivabradine group (n=30). - The baseline evaluation comprised physical examination, NYHA class, 12-lead electrocardi¬ography (ECG), Echocardiography, blood sampling for laboratory measurements, including NT-Pro BNP and Neopterin. - Patients in the Ivabradine group were administered Ivabradine 5 mg twice daily and doses (2.5, 5, 7.5 mg) were to be adjusted upwards or downwards at every visit according to HR at rest and tolerability. - Patients were followed up after 1 week of initiation of ivabradine therapy then monthly till the end of the study. - Peripheral venous blood samples were drawn between 8 and 9 am after a 30-min rest in the supine position. Serum samples were frozen at -80°C until assay. - Levels of NT-Pro BNP and Neopterin were detected using ELISA kits as prescribed by manufacturer. - Statistical tests appropriate to the study will be conducted to evaluate significance of results - Results, conclusion, discussion and recommendations will be given ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04448899
Study type	Interventional
Source	Damanhour University
Contact
Status	Completed
Phase	Phase 4
Start date	June 1, 2020
Completion date	February 5, 2021

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT04115735` - His Bundle Recording From Subclavian Vein
Recruiting	`NCT05562037` - Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA	N/A
Completed	`NCT05563701` - Evaluation of the LVivo Image Quality Scoring (IQS)
Recruiting	`NCT05865184` - Evaluation of Home-based Sensor System to Detect Health Decompensation in Elderly Patients With History of CHF or COPD
Completed	`NCT04037436` - Functional Exercise and Nutrition Education Program for Older Adults	N/A
Recruiting	`NCT04703842` - Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction	Phase 1/Phase 2
Terminated	`NCT05594940` - Heart Failure Monitoring With a Portable Ultrasound Device With Artificial Intelligence Assisted Tools: A Multi-Phase Observational Feasibility Study
Recruiting	`NCT04982081` - Treating Congestive HF With hiPSC-CMs Through Endocardial Injection	Phase 1
Completed	`NCT04394754` - Evaluating Efficacy of Digital Health Technology in the Treatment of Congestive Heart Failure	N/A
Active, not recruiting	`NCT01385176` - Neural Cardiac Therapy for Heart Failure Study (NECTAR-HF)	N/A
Not yet recruiting	`NCT05516290` - Evaluating Clinical Trial Experiences of Individuals With Congestive Heart Failure
Completed	`NCT02885636` - Inhaled Beta-adrenergic Agonists to Treat Pulmonary Vascular Disease in Heart Failure With Preserved EF (BEAT HFpEF): A Randomized Controlled Trial	Phase 3
Terminated	`NCT02788656` - Pulmonary Artery Pressure Reduction With ENTresto (Sacubitril/Valsartan)	Phase 4
Completed	`NCT02252757` - Assess Measurements of Wireless Cardiac Output Device	N/A
Terminated	`NCT02205411` - Clinical Trial to Evaluate the the ReliantHeart HeartAssist 5® VAD System in Patients Awaiting Heart Transplantation	N/A
Completed	`NCT01362855` - Advance Care Planning Evaluation in Hospitalized Elderly Patients
Completed	`NCT01476995` - Prognostic Indicators as Provided by the EPIC ClearView	N/A
Withdrawn	`NCT00346177` - Stem Cell Study for Patients With Heart Failure	Phase 2
Active, not recruiting	`NCT01058837` - SCD-HeFT 10 Year Follow-up	N/A
Completed	`NCT00957541` - Evaluation of a Diagnostic Feature in a Cardiac Resynchronization Therapy (CRT) Device	Phase 2