Congestive Heart Failure: Causes of Sudden Worsening

Congestive Heart Failure Clinical Trial

Official title:

Congestive Heart Failure: Causes of Sudden Worsening

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01081925
• Other study ID #: MSM0021620817-HKJC
• Status: Recruiting
• Phase: N/A
• First received: March 4, 2010
• Last updated: March 4, 2010
• Start date: February 2010
• Est. completion date: February 2012

Study information

• Verified date: February 2010
• Source: University Hospital Hradec Kralove
• Contact: Radek Pelouch, MD
• Phone: 00420495834740
• Email: pelouch[@]centrum.cz
• Is FDA regulated: No
• Health authority: Czech Republic: Ethics Committee
• Study type: Observational

Clinical Trial Summary

The purpose of the study is to recognize main causes of acute decompensation of chronic congestive heart failure.

Description:

Congestive heart failure (CHF) presents a very significant cause of morbidity and mortality. The prevalence of CHF is between 2 and 4% and rises with age (in 70- to 80-year-old people is between 10 and 20%). CHF is the cause of 5% of all acute hospital admissions and accounts for 2% of expenses on health. The most common causes of worsening of the chronic CHF are ischemia, arrhythmias, valvular dysfunction, systemic or pulmonary hypertension, volume overload or fluid retention, high output conditions (infection, anemia, thyrotoxicosis), drugs (NSAIDs, cyclo-oxygenase (COX) inhibitors, thiazolidinediones) and medication nonadherence. The goal of this study is to determine the proportion of various reasons of acute worsening of CHF, using commonly available methods including assessment of serum drug levels.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: February 2012
• Est. primary completion date: February 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• able to provide informed consent

• aged 19 years or more

• history of heart failure of at least one month

• examined or hospitalized for acute dyspnea at rest or with minimal exertion

• clinical signs of fluid overload defined as at least one of following:

• rales

• jugular venous distension

• peripheral edema

• pulmonary congestion on X-ray

• NT-proBNP above 210 pmo/l

Exclusion Criteria:

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Congestive Heart Failure
• Heart Failure

Locations

Country	Name	City	State
Czech Republic	University Hospital Hradec Kralove	Hradec Kralove

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital Hradec Kralove

Country where clinical trial is conducted

Czech Republic,