Congestive Heart Failure Clinical Trial
Official title:
Long-Acting Testosterone Improves Exercise Oxygen Uptake, Insulin Resistance and Muscle Strength in Elderly Patients With Chronic Heart Failure
Background: Patients with congestive heart failure (CHF) show muscle mass wasting and
decreased testosterone levels. Long-term testosterone supplementation improves walking
distance and glucose metabolism of patients CHF. No studies have investigated the integrated
effects of testosterone on exercise oxygen uptake muscle strength and glucose metabolism in
patients with CHF regardless of the presence of hypogonadism.
Aim: To assess the effect of a 12 week testosterone administration on maximal exercise
capacity, muscle strength and insulin resistance in elderly CHF patients.
Methods: Seventy elderly patients with stable CHF, mean age 71 ± 8 years, ejection fraction
34 ± 1%, NYHA class II/III 38/32, were enrolled. Of these, 35 were randomized to receive
testosterone therapy (through intramuscular injection every 6 week) and 35 to receive
placebo both on top of maximal medical therapy. At baseline and after 12 weeks all patients
underwent echocardiogram, cardiopulmonary test, 6-minute walking test (6MWT), quadriceps
maximal isometric and isokinetic strength.
n/a
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