Congenital Heart Disease Clinical Trial
Official title:
Copeptin- Relevance as a Perioperative Marker in Pediatric Cardiac Surgery
This study evaluates the relevance of Copeptin in children with congenital heart disease undergoing cardiac surgery with the need of cardiopulmonary bypass. Three blood samples are taken of each patient. The first and second sample are collected in the operation room before and after the procedure and the third sample on the first postoperative day at the intensive care unit.
Objective:
Vasopressin is a hormone secreted by the posterior pituitary gland. Its main functions are
constriction of blood vessels and reabsorption of water and thereby regulating water balance
and hemodynamics of the body. Copeptin is a cleavage product in the synthesis of vasopressin
and is released in equimolar amounts. Its stability makes it easier to determine the amount
of vasopressin. It is known, that the use of a heart-lung machine in cardiac procedures has
effects on the water balance of the body and may affect the vasopressin secretion.
The aim of this prospective clinical trial is, to figure out if copeptin would be suitable
for perioperative risk evaluation in neonates and children with congenital heart disease
after surgery with the use of a heart-lung machine.
Hypotheses:
The primary outcome endpoint of this study is the change in copeptin concentration
perioperatively in patients with congenital heart disease, with the use of heart-lung
machine.
Secondary outcome endpoints are correlations between copeptin concentration and complexity of
the procedure (based on the aristotle basic score), clinical status and the perfusion times
of the heart-lung machine.
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