Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy

Congenital Cataract Clinical Trial

Official title:

Expression Profile of Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04120818
• Other study ID #: yyzhao
• Status: Completed
• Start date: March 4, 2016
• Est. completion date: February 12, 2017

Study information

• Verified date: September 2019
• Source: Wenzhou Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In this prospective study , a cohort of 58 eyes with congenital cataract from Wenzhou medical university was erolled.33 eyes with congenital cataract was after lensectomy and anterior vitrectomy as post-surger group, 26 eyes without cataract surgery as control group. The cytokines of MCP-1, VEGF, IL-1, IFN-γ, IL-1r,IL-4,IL-17, IL-2,IL-5,G-CSF,IL-12, IL-15 was evaluated

Description:

Secondary IOL implantation in aphika children and lensectomy and anterior vitrectomy and primary IOL implantation in children with congenital cataract were both performed by the same surgeon(Z.Y.E) and videos were collected to review the capsular reconstruction condition and lens implantation position.

Aqueous humor (100-200 μl) was aspirated from each patient before the surgery. The research was to evaluate the relationship between the cytokine profile in aqueous humor and the state of capsule after Lensectomy and Anterior Vitrectomy.Aqueous humor was obtained , Human Magnetic Luminex Screening Assay was used to determine the aqueous humor levels of cytokines.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 59
• Est. completion date: February 12, 2017
• Est. primary completion date: February 12, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 10 Months to 72 Months

Eligibility

Inclusion Criteria: aphakic children diagnosed with congenital cataract who underwent secondary IOL implantation and children with congenital cataract who underwent lensectomy and anterior vitrectomy and primary IOL implantation

Exclusion Criteria:patients with mild cataracts do not require surgery

-

Related Conditions & MeSH terms

• Cataract
• Congenital Cataract

Intervention

Procedure:
• secondary IOL implantation
reopened the fibrotic, closed capsular bag and achieve IOL placement
• primary IOL implantation
lensectomy and anterior vitrectomy and primary IOL implantation

Locations

Country	Name	City	State
China	Eye Hosptial of Wenzhou Medical College	Wenzhou	Zhejiang
China	Ophthalmology and Optometry Hospital	Wenzhou	Zhejiang

Sponsors (1)

Lead Sponsor	Collaborator
yin ying zhao

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	inflammatory cytokines	investigate inflammatory microenvironment changes in the aqueous of children after surgery.aqueous humor levels of cytokines, chemokines and growth factors including TGFß2, TNF-a, IL-6, IP10, IL-10, MCP-1, VEGF, IL-1, IFN-?, IL-1r,IL-4,IL-17, IL-2,IL-5,G-CSF,IL-12, IL-15.	before the surgery of secondary IOL implantation