Congenital Cataract Clinical Trial
Official title:
Analysis of Retinal Nerve Fiber Layer and Macular Thickness After Congenital Cataract Surgery
Congenital cataract is the main cause of form deprivation amblyopia in children. Current studies confirm that form deprivation amblyopia affects the retinal nerve fiber layer. However, there are different opinions about the effect of amblyopia on the optic nerve fiber thickness around the optic disc at home and abroad. Investigators have performed "cataract extraction with IOL implantation" on children with bilateral and unilateral congenital cataract. Investigators used OCT biometry to measure children's the retinal nerve fiber layer (RNFLT) and macular thickness (CMT) before and after surgery. Investigators dynamically observed changes in RNFL and CMT to explore the retinal mechanism of form deprivation amblyopia and help guide the clinical correct understanding of postoperative follow-up time.
This prospective study reviewed children with CC who were undergoing cataract extraction with
IOL implantation at the Eye Hospital of Wenzhou Medical University, Hangzhou, China.
bilateral and unilateral CC children were placed in Study group, while age-matched normal
children were included as controls. Children who were uncooperative to complete the
preoperative and postoperative examinations were excluded.
All eyes were divided into 4 groups. Group 1: form deprivation amblyopia of unilateral CC,
Group 2: unaffected eyes of unilateral CC, Group 3: form deprivation amblyopia of bilateral
CC, Group 4: normal eyes of normal children. The preoperative and postoperative data
including sex, age at surgery, 7 position of RNFLT and CMT were collected.
All surgeries were performed by the same surgeon (Y.E.Z.) under general anesthesia.
Investigators used OCT biometry to measure participants' the retinal nerve fiber layer
(RNFLT) and macular thickness (CMT) before surgery and 1 week, 1 month, 3 months, and 6
months and 1 year after surgery, and compared with age-matched normal children.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05136209 -
Comparison of Posterior Continuous Curvilinear Capsulorhexis With or Without Anterior Vitrectomy
|
N/A | |
| Recruiting |
NCT05275764 -
Comparison of the Efficacy of Intraocular Lens Optic Capture and In-the-bag Implantation Over 1 Year in Children With Congenital Cataract
|
||
| Recruiting |
NCT03342794 -
Morphologic and Biometric Characteristics of Preexisting Posterior Capsule Defects in Congenital Cataracts During the First Year of Life
|
N/A | |
| Completed |
NCT01297153 -
Aphakia Versus Pseudophakia in Children Under 2 Years Undergoing Bilateral Congenital Cataract Surgery
|
Phase 4 | |
| Completed |
NCT04120818 -
Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy
|
||
| Recruiting |
NCT04824963 -
Analysis of Related Factors Affecting the Secondary Implantation of Intraocular Lens in Congenital Cataract
|
||
| Recruiting |
NCT04323982 -
Comparison of Traditional Cataract Surgery and Traditional Surgery Combined Triamcinolone Staining
|
N/A | |
| Completed |
NCT02158325 -
Capsulorhexis Size and Capsular Outcome
|
N/A | |
| Recruiting |
NCT03564990 -
The Impact of Interactive, Multifaceted Approach Education on Congenital Cataract
|
N/A | |
| Not yet recruiting |
NCT05282147 -
Digital Imaging Versus Ophthalmoscopy
|
N/A | |
| Not yet recruiting |
NCT03125785 -
The Effect of Ophthalmic Solutions on Contact Lenses Used After Surgery for Congenital Cataract Investigated in Vivo
|
N/A | |
| Recruiting |
NCT04976608 -
Relationship of Retinal and Visual Cortex Structure and Visual Acuity After Congenital Cataract Surgery
|
||
| Completed |
NCT03778086 -
Iridocorneal Angle and Anterior Segment Structure in Eyes of Children With Cataract
|
||
| Recruiting |
NCT03230799 -
Comparison of Minimal Invasive Lens Surgery and Traditional Cataract Surgery
|
N/A | |
| Recruiting |
NCT04759560 -
Biometric Characteristics of the Eye With Microcornea/Microphthalmia and Congenital Cataract Before And After Cataract Extraction
|
||
| Completed |
NCT02132312 -
A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement
|
Phase 3 | |
| Completed |
NCT01136473 -
Mechanism of Aphakic and Pseudophakic Glaucoma in Pediatric Patients
|
N/A | |
| Completed |
NCT03242629 -
Comparison Between Oral and Enema of Chloral Hydrate
|
N/A | |
| Completed |
NCT04077489 -
Effects of 23-gauge Lensecotomy Combined With Anterior Vitrectomy on Macular in Children With Congenital Cataract
|
N/A | |
| Active, not recruiting |
NCT05451745 -
Glaucoma Following Pediatric Cataract Surgery
|