Congenital Cataract Clinical Trial
Official title:
A Novel Prophylactic Peripheral Iridectomy Prevents Aphakic Angle-closure Glaucoma After Congenital Cataract Surgery
Verified date | March 2019 |
Source | Zhongshan Ophthalmic Center, Sun Yat-sen University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This is a retrospective, nonrandomized comparative trial with historical control to investigate the safety and efficacy of a novel progressive grasping peripheral iridectomy (PGPI) surgical method in preventing aphakic angle-closure glaucoma (AACG) following congenital cataract surgery.
Status | Completed |
Enrollment | 87 |
Est. completion date | March 5, 2019 |
Est. primary completion date | March 5, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 2 Months to 24 Months |
Eligibility |
Inclusion Criteria: 1. patients less than 2 years old; 2. patients performed with congenital cataract surgery with or without PPI; 3. patients with routine follow-up at ZOC. Exclusion Criteria: 1. patients with IOP =21 mm Hg or with congenital glaucoma or with a family history of glaucoma; 2. patients with keratopathy, retinopathy, ocular trauma, radiation therapy or intraocular surgery; 3. patients associated with other congenital ocular anomalies, such as anterior segment dysgenesis, microcornea/microphthalmia, persistent fetal vasculature, lens dislocation and iridocoloboma; 4. patients with systemic diseases, such as Down's syndrome, Lowe syndrome, Stickler syndrome, maternal rubella syndrome or trisomy 13. |
Country | Name | City | State |
---|---|---|---|
China | State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University | Guangzhou | Guangdong |
China | Zhongshan Ophthalmic Center, Sun Yet-san University | Guangzhou | Guangdong |
Lead Sponsor | Collaborator |
---|---|
Zhongshan Ophthalmic Center, Sun Yat-sen University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The rate of aphakic angle-closure glaucoma | Pupillary block with subsequent closure of the filtration angle is the cause of early aphakic angle-closure glaucoma (AACG), which usually happens in the early postoperative period, generally within the first 6 months. AACG presents with elevated IOP (repeatedly >25 mmHg), corneal edema, iris bombe, shallow anterior chamber, peripheral anterior synechia and angle closure. | 18-49 months | |
Secondary | The rate of iris posterior synechia | Postoperative uveal inflammation can result in iris posterior synechia (IPS), referring to the synechia between iris and capsule around pupil. IPS is graded according to the range of the synechia. Grade 0: no synechia; Grade I: <1 quadrant; Grade II: =2 quadrants and >1 quadrant ; Grade III: =3 quadrants and >2 quadrants; Grade IV: >3 quadrants. | 18-49 months | |
Secondary | The rate of visual axis opacity | visual axis opacification (VAO) refers to developing reopacification of the visual axis in the form of lens proliferation into the visual axis or pupillary membrane. | 18-49 months |
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