Congenital Cataract Clinical Trial
Official title:
Mechanism of Aphakic and Pseudophakic Glaucoma in Pediatric Patients: Exploring the Pathophysiology Through Lens Epithelial Cell Culture and Isolation of Candidate Factors From Aqueous Humor
In cell cultures, lens epithelial cells and trabecular meshwork cells will be exposed to aqueous humor from pediatric eyes undergoing cataract removal surgery. Cytokine analysis of candidate factors will be performed before and after exposure to lens epithelial.
Aqueous from the anterior chamber will be withdrawn before surgery. Then the lens capsule
will be opened (capsulorhexis) and removed. The lens material will be removed. All 3
components will be sent to the lab.
Lens epithelial cells will be isolated and will be used in a co-culture setup with
trabecular cells to investigate the interactions between lens cells and trabecular cells.
Understanding the interaction between young and adult lens cells on trabecular cell will
shed light on mechanism of infantile aphakic glaucoma.
Aqueous humor taken out before cataract surgery and before glaucoma operation of aphakic
eyes will be used for analysis of growth factor and cytokines in the Aphakic eye using
proteins membrane arrays. Eyes before cataract surgery will be used as controls. Such
analysis will shed light on the possible factors affecting trabecular cells in aphakic eye.
;
Observational Model: Case-Only, Time Perspective: Cross-Sectional
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05136209 -
Comparison of Posterior Continuous Curvilinear Capsulorhexis With or Without Anterior Vitrectomy
|
N/A | |
| Recruiting |
NCT05275764 -
Comparison of the Efficacy of Intraocular Lens Optic Capture and In-the-bag Implantation Over 1 Year in Children With Congenital Cataract
|
||
| Recruiting |
NCT03342794 -
Morphologic and Biometric Characteristics of Preexisting Posterior Capsule Defects in Congenital Cataracts During the First Year of Life
|
N/A | |
| Completed |
NCT01297153 -
Aphakia Versus Pseudophakia in Children Under 2 Years Undergoing Bilateral Congenital Cataract Surgery
|
Phase 4 | |
| Completed |
NCT04120818 -
Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy
|
||
| Recruiting |
NCT04824963 -
Analysis of Related Factors Affecting the Secondary Implantation of Intraocular Lens in Congenital Cataract
|
||
| Recruiting |
NCT04323982 -
Comparison of Traditional Cataract Surgery and Traditional Surgery Combined Triamcinolone Staining
|
N/A | |
| Completed |
NCT02158325 -
Capsulorhexis Size and Capsular Outcome
|
N/A | |
| Completed |
NCT03621579 -
Analysis of Retinal Nerve Fiber Layer and Macular Thickness After Congenital Cataract Surgery
|
N/A | |
| Recruiting |
NCT03564990 -
The Impact of Interactive, Multifaceted Approach Education on Congenital Cataract
|
N/A | |
| Not yet recruiting |
NCT05282147 -
Digital Imaging Versus Ophthalmoscopy
|
N/A | |
| Not yet recruiting |
NCT03125785 -
The Effect of Ophthalmic Solutions on Contact Lenses Used After Surgery for Congenital Cataract Investigated in Vivo
|
N/A | |
| Recruiting |
NCT04976608 -
Relationship of Retinal and Visual Cortex Structure and Visual Acuity After Congenital Cataract Surgery
|
||
| Completed |
NCT03778086 -
Iridocorneal Angle and Anterior Segment Structure in Eyes of Children With Cataract
|
||
| Recruiting |
NCT03230799 -
Comparison of Minimal Invasive Lens Surgery and Traditional Cataract Surgery
|
N/A | |
| Recruiting |
NCT04759560 -
Biometric Characteristics of the Eye With Microcornea/Microphthalmia and Congenital Cataract Before And After Cataract Extraction
|
||
| Completed |
NCT02132312 -
A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement
|
Phase 3 | |
| Completed |
NCT03242629 -
Comparison Between Oral and Enema of Chloral Hydrate
|
N/A | |
| Completed |
NCT04077489 -
Effects of 23-gauge Lensecotomy Combined With Anterior Vitrectomy on Macular in Children With Congenital Cataract
|
N/A | |
| Active, not recruiting |
NCT05451745 -
Glaucoma Following Pediatric Cataract Surgery
|