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Congenital Abnormalities clinical trials

View clinical trials related to Congenital Abnormalities.

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NCT ID: NCT02744365 Recruiting - Preterm Birth Clinical Trials

Biobank on Prematurity, Preeclampsia and Other Pregnancy Complications

Start date: April 2015
Phase:
Study type: Observational

The Biobank includes data and biological specimens of women from three original studies: 1) First-trimester Prediction of Preeclampsia (PREDICTION Study, NCT02189148), 2) Pre-Eclampsia And growth Retardation, an evaluative Longitudinal study (PEARL Study, NCT02379832), 3) Effect of Low Dose Aspirin on Birthweight in Twins: The GAP Trial (NCT02280031) and 4)PREDICTION2: Prediction of Preeclampsia and other Pregnancy Complications Following Combined Iterative Screening.

NCT ID: NCT02716545 Recruiting - Clinical trials for Gastrointestinal Vascular Malformation

the Efficiency of Endoscopic Treatment for Recurrent Small Intestinal Bleeding Due to Gastrointestinal Vascular Malformation

Start date: March 2016
Phase: N/A
Study type: Interventional

Gastrointestinal vascular malformation (GIVM), which is an important cause of acute or chronic gastrointestinal bleeding, consequently is in dire of effective treatment. The investigators' previous study first confirmed thalidomide treatment of GIVM bleeding was safe and effective. This trial intends to investigate the efficiency of endoscopic intervention to the hemorrhage due to GIVM. What more, the research tends to suggest standardizing clinical paths for small bowel bleeding due to GIVM.

NCT ID: NCT02691689 Recruiting - Clinical trials for Pulmonary Arterial Hypertension

Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions

Start date: November 2015
Phase: N/A
Study type: Interventional

Pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD) is associated with considerable morbidity and even mortality. Next to environmental risk factors, the investigators believe that there is an important role of genetic predisposition to develop PAH in CHD. There often is a discrepancy between the severity of PAH and the CHD, where it is useful to screen for PAH gene mutations. The investigators hypothesize that the genotype is partly responsible for the phenotypic variability in patients with congenital shunt lesions, where some develop PAH and others do not. If a genetic predisposition for PAH in CHD could be identified, then genetic screening could be a useful additional tool for early detection of patients at risk of pulmonary vascular disease and PAH development, with new opportunities for prevention or early treatment.

NCT ID: NCT02660203 Recruiting - Child Clinical Trials

Impact of Forced Expiration On Pleural Drainage Duration (KPDP)

KPDP
Start date: May 2016
Phase: N/A
Study type: Interventional

Following thoracic surgery, pleural effusion in pleural cavity requires post-operative drainage. Pleural effusion is responsible for pulmonary congestion, atelectasis, hypoventilation, lower efficacy of diaphragmatic curse, lower pulmonary reexpansion and vicious attitude. These complications could be avoided by respiratory physiotherapy. Forced expiration technic in ipsilateral decubitus is one of these technics but has never been proved better than other technics regarding its efficiency. The aim of the study is to compare the impact of such a technic on post operative thoracic drainage after pulmonary, pleural or mediastinal pediatric surgery.

NCT ID: NCT02622152 Recruiting - Clinical trials for Heart Defects, Congenital

Right Lateral Positioning of Postoperative Pediatric Cardiac Surgery

Start date: January 30, 2016
Phase: N/A
Study type: Interventional

Directly following cardiac surgery for congenital heart disease; patients are not receiving routine turning every two hours to prevent pressure ulcers, because a negative influence on hemodynamic parameters is assumed. Investigators have suggested that lateral position may have clinically significant effects on oxygenation in cardiac surgery patients.

NCT ID: NCT02595307 Recruiting - Clinical trials for Musculoskeletal Diseases

Improving Informed Consent for Cleft Palate Repair

Start date: May 2014
Phase: N/A
Study type: Interventional

To determine if providing a written document in addition to the standard oral discussion of surgical risks improves risk recall for the parents/guardians of a child seen in consultation for cleft palate surgery, and if this has any effect on overall satisfaction after the procedure

NCT ID: NCT02582762 Recruiting - Nail Abnormalities Clinical Trials

Pilot Study of Efficacy of Nail Gel in Finger Nail Surface Abnormality

Start date: September 2015
Phase: Phase 3
Study type: Interventional

Nail surface abnormalities is any conditions that affect the nail matrix or nail bed which cause nail plates grow defectively. Common nail surface abnormalities are pitting nails, longitudinal ridging, and transverse ridging/Beau's line. Aging nails usually have nail surface abnormalities as well. Nail gels are artificial nails used widely for aesthetic purposes. Although, their cosmetic use is increasing with day by day, their usefulness in conditions such as nail biting, brittle nails, and ingrown toe nails has been reported. Moreover, a previous study reported the benefits of nail gels in terms of improving nail surface abnormalities like pitting nails, trachyonychia, and onychoschizia. This study was conducted to evaluate the efficacy of nail gel containing Glycerin which has humectant effect and Artemisia Abrotanum extract which has anti-fungal/bacterial activities in finger nail surface abnormalities.

NCT ID: NCT02552459 Recruiting - Clinical trials for Arteriovenous Malformation

Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery

Start date: September 2015
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine effect of combined medication of sufentanil and dexmedetomidine in patient controlled analgesia after neurosurgery.

NCT ID: NCT02551081 Recruiting - Genetic Disease Clinical Trials

Genomic Sequencing and Personalized Treatment for Birth Defects in Neonatal Intensive Care Units

Start date: October 1, 2015
Phase:
Study type: Observational

The purpose of study is to evaluate the benefits of using the Next Generation Sequencing Technology to diagnose birth defects and genetic diseases. The results from genomic sequencing can also significantly shorten the time of examination, improve the diagnosis rate, guide the clinical treatments. So the ultimate goal is individualized or personalized therapy and promote prognosis.

NCT ID: NCT02530983 Recruiting - Esophageal Cancer Clinical Trials

Mayo Clinic Upper Digestive Disease Survey

UDD
Start date: August 2015
Phase:
Study type: Observational

The Mayo Clinic Conduit Report Card Questionnaires have been created in order to have a consistent evaluation tools for patients undergoing esophageal reconstruction or treatment or patients that are experiencing an upper digestive disease in order to standardize and validate outcome measures. Data will be used to establish the validation of the questionnaires/survey. Data will also lead to the establishment of "normal" or expected scores for patients undergoing each type of esophagectomy procedure and for upper digestive diseases. Data will contribute to creating treatment algorithms for symptom management for upper digestive diseases and for post-operative complications and symptoms as well as contribute to pre-operative education.