Compliance, Patient Clinical Trial
Official title:
A Randomised Controlled Trial of a 12-dose Rifapentine and Isoniazid (RPT+INH) Regimen Using Direct Observed Therapy (DOT) Versus 6 Months of Daily Isoniazid for Latent Tuberculosis Infection (LTBI) in Socially Marginalised People
An open-label, randomised controlled trial comparing compliance to treatment for latent tuberculosis infection in socially marginalised citizens. Participants will be randomized to either daily isoniazid for 6 months or weekly rifapentine and isoniazid as directly observed therapy for twelve weeks.
Eligible participants will be randomised to receive either daily isoniazid for 6 months with monthly visits for pill count, evaluation of adverse events and dispensing of isoniazid for the next month, or weekly doses of rifapentine and isoniazid for twelve weeks as direct observed therapy where the drugs are administered in the presence of a study nurse or doctor. Control bloodsamples (ALAT, alkaline phosphatase, bilirubin, INR, haemoglobin, trombocytes and leukocyte differential count) will be taken at baseline and at least once during treatment in the rifapentine and isoniazid group and at least twice in the isoniazid-only group. One year after treatment completion participants will be called in for evaluation for active tuberculosis. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04874467 -
Influence of Keratinized Mucosa on Dental Implants With Mucositis
|
N/A | |
Not yet recruiting |
NCT06017063 -
Coaching for Coping in Glioblastoma Patients and Caregivers and Its Association With Compliance to TTFields
|
N/A | |
Completed |
NCT04231149 -
Explorative Clinical Study on the Performance and Acceptance of New Intermittent Catheters in Healthy Volunteers
|
N/A | |
Recruiting |
NCT06411847 -
The Effectiveness of Virtual Appointments on Compliance With Twin Block Wear
|
N/A | |
Completed |
NCT03748576 -
A Prospective Randomized Controlled Trial of Mobile Medical Used for Management of Pregnant Women
|
N/A | |
Recruiting |
NCT05157113 -
Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population
|
Phase 4 | |
Recruiting |
NCT05231473 -
Impact Of The Nurse Enhanced Recovery After Surgery Coordinator On The Compliance In Colorectal Surgery (nursERAS-BCN)
|
N/A | |
Completed |
NCT03925168 -
Music Therapy and Dialysis: A Pilot Investigation Into the Effectiveness of Patient-Selected Music Interventions on Physiological, Psychological, and Quality-of-Life Outcomes
|
N/A | |
Completed |
NCT04250987 -
Exploratory Investigation of Data Obtained From a Sensor Connected to an Intermittent Catheter
|
N/A | |
Completed |
NCT04870632 -
Telerehabilitation Improves QoL, Physical Functions and Compliance in Patients With COPD
|
N/A | |
Active, not recruiting |
NCT04424238 -
the Effect of Mobile Medical Used for the Standardized Management of Gestational Diabetes
|
N/A | |
Terminated |
NCT04041908 -
Use of a Medical Food in Adults Undergoing Surgery
|
N/A | |
Active, not recruiting |
NCT05308914 -
Self-Management and Resilience Trajectories in African American Adults With Hypertension
|
||
Completed |
NCT06203665 -
Restoration of Pulmonary Compliance After Laparoscopic Gynaecologic Surgery Using a Recruitment Maneuver
|
N/A | |
Recruiting |
NCT06464003 -
Orthodontic Screening in Public Healthcare
|
||
Completed |
NCT06055335 -
Assessing Lung Dynamics and Respiratory Functions in Minimal Flow Anesthesia: A Prospective Study
|
N/A | |
Completed |
NCT03197116 -
Lay Tel Compliance Study
|
N/A | |
Completed |
NCT03792880 -
Global Self-management Telematic Support for Patients With Obstructive Sleep Apnea.
|
N/A | |
Recruiting |
NCT04877171 -
Telemedicine Efficacy in Medication Adherence in Post-ischemic Stroke Patients
|
N/A | |
Recruiting |
NCT05749419 -
Vaccinations and People With Disabilities
|