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Clinical Trial Summary

This is a randomized, open-label, dose/schedule optimization study comparing NUC-3373/leucovorin (LV)/irinotecan plus bevacizumab (NUFIRI-bev) to 5-FU/LV/irinotecan plus bevacizumab (FOLFIRI-bev) for the treatment of patients with unresectable metastatic colorectal cancer. A total of 171 patients will be randomized 1:1:1 to either NUFIRI-bev on a weekly NUC-3373 schedule, NUFIRI-bev based on an alternate weekly NUC-3373 schedule, or FOLFIRI bev on an alternate weekly schedule. The main objectives are to assess and compare the efficacy and safety of the 3 regimens. Pharmacokinetics will be assessed on the 2 NUFIRI arms.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05678257
Study type Interventional
Source NuCana plc
Contact Bryn Dixon
Phone +44 (0)357 1116
Email bryndixon@nucana.com
Status Recruiting
Phase Phase 2
Start date January 2023
Completion date December 2024

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