Colorectal Cancer Clinical Trial
Official title:
A Prospective Study of Integrative Omics Analysis for Colorectal Cancer and Metastasis
NCT number | NCT05482529 |
Other study ID # | IOACCM |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | August 1, 2022 |
Est. completion date | December 31, 2025 |
The pathogenesis of Colorectal cancer (CRC) metastasis remains unclear.We collect clinical data from our center and use Integrative omics to analyze and predict candidate biomarkers of colorectal cancer and distant metastasis.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | December 31, 2025 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - colorectal adenocarcinoma by biopsy? - at least 1 metastasis lesion comfirmed by at least 1 kind of imaging examination (CT, MRI and PET-CT ) Exclusion Criteria: - recent diagnosis with other malignancies - can not tolerate the surgery - history of serious mental illness - pregnancy or lactating women - the researchers believe the patients should not enrolled in |
Country | Name | City | State |
---|---|---|---|
China | Daping hospital | Chongqing |
Lead Sponsor | Collaborator |
---|---|
fan li |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | overall survival rate | the oncological efficacy by 3-year follow-up according to the NCCN guideline. Participants should report every follow-up examinations which prove tumor recurrence and/or metastasis or not. | 3 years after surgery | |
Primary | disease free survival rate | the oncological efficacy by 3-year follow-up according to the NCCN guideline. Participants should report every follow-up examinations which prove tumor recurrence and/or metastasis or not. | 3 years after surgery | |
Secondary | Quality of life outcomes evaluation(QLQ-CR38) | We examine before operation, 3 months after, 6 months after, 12 months after, 24 months after operation, by questionnaires (HRQoL).The General quality of life quality of life Questionnaires of Colorectal Cancer-38(QLQ-CR38) are used to evaluate the Quality of life outcomes. Items are scored on a four-point scale from 1("not at all) to 4 ("very much"). Raw scores are aggregated and converted to a linear scale ranging from 0 to 100, with higher scores representing a higher level of functioning or a higher level of symptoms | 0- 2 years after surgery | |
Secondary | Quality of life outcomes evaluation(QLQ-C30) | We examine before operation, 3 months after, 6 months after, 12 months after, 24 months after operation, by questionnaires (HRQoL).The General quality of life Quality of life Questionnaires of Cancer-30 (QLQ-C30) are used to evaluate the Quality of life outcomes. Items are scored on a four-point scale from 1("not at all) to 4 ("very much"). Raw scores are aggregated and converted to a linear scale ranging from 0 to 100, with higher scores representing a higher level of functioning or a higher level of symptoms | 0- 2 years after surgery | |
Secondary | R0 resection rate | The R0 resection rate by pathology outcome of specimen | 2 weeks after surgery |
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