Colorectal Cancer Clinical Trial
Official title:
Resection of Colorectal Liver Metastases With or Without Routine Hilar Lymphadenectomy - A Randomized Controlled Trial
It is uncertain, whether hilar lymphadenectomy should be performed routinely in patients
undergoing resection of colorectal liver metastases.
For this reason it is the aim of the present prospective randomized trial to evaluate, if
routine lymphadenectomy reduces recurrent disease in patients undergoing resection of
colorectal liver metastases.
Routine lymphadenectomy in patients undergoing hepatic resection for colorectal liver
metastases may improve outcome of further patients due to the presence of micrometastases
that have been shown to be of prognostic relevance. While previous studies highlight the
clinical significance of perihepatic lymph node metastases, the outcome of patients with and
without hilar lymphadenectomy has not yet been compared and thus no clear conclusion about
the clinical value of routine hilar lymphadenectomy in CRC patients undergoing resection of
liver metastases can be drawn from present data.
As disease recurrence occurs frequently and may affect up to 75 % of patients, further
strategies are required to improve postoperative outcome. Routine hilar lymphadenectomy may
offer an effective approach to remove residual disease and by this to reduce disease
recurrence with little additional morbidity. For this reason it is the aim of the present
prospective randomized trial to evaluate, if routine lymphadenectomy reduces recurrent
disease in patients undergoing resection of colorectal liver metastases.
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