Colorectal Cancer Clinical Trial
Official title:
Gene Expression Profiling of Metastatic Colon Cancer (CCCWFU 89B03)
RATIONALE: Studying the genes expressed in samples of tissue from patients with cancer may
help doctors identify biomarkers related to cancer.
PURPOSE: This laboratory study is using gene expression profiling to evaluate normal tissue
and tumor tissue from patients with colon cancer that has spread to the liver, lungs, or
peritoneum.
OBJECTIVES:
- Evaluate gene expression profiles in normal and tumor tissue from patients with colon
cancer metastatic to the liver, lungs, or peritoneum.
- Establish cell lines from primary colon tumors metastatic to the liver, lungs, or
peritoneum.
- Determine the specific gene expression changes that result in the manifestation of the
drug-resistant phenotype for each metastatic site.
OUTLINE: This is a pilot study.
Tumor and normal tissue collected during surgery are analyzed for gene expression profiling
by cDNA microarray. Tissue is also analyzed for thymidylate synthase (TS) gene expression by
quantitative PCR and for protein expression by western blot. Gene expression patterns are
correlated with TS levels.
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