Colorectal Cancer Clinical Trial
Official title:
Detection of Residual Colorectal Liver Metastases Within 24 Hours After RFA With 18-F FDG PET
RATIONALE: Diagnostic procedures, such as fludeoxyglucose F 18-PET imaging, may be effective
in detecting residual disease after radiofrequency ablation of liver metastases in patients
with colorectal cancer.
PURPOSE: This clinical trial is studying fludeoxyglucose F 18-PET imaging to see how well it
works for early detection of residual disease in patients undergoing radiofrequency ablation
of liver metastases from colorectal cancer.
OBJECTIVES:
Primary
- Determine the sensitivity and specificity of fludeoxyglucose F 18 (FDG)-PET imaging in
detecting residual disease within 48 hours after radiofrequency ablation (RFA) of liver
metastases in patients with colorectal cancer.
Secondary
- Determine the findings on day 7 after RFA using FDG-PET imaging in these patients.
OUTLINE: This is a prospective study.
Patients undergo fludeoxyglucose F 18 (FDG)-PET imaging at baseline. They then undergo
percutaneous laparoscopic or intraoperative radiofrequency ablation (RFA). Patients then
undergo further FDG-PET scans within 48 hours and 7 days after RFA. FDG-PET images are
evaluated for residual disease, including focal FDG uptake at the site of ablation.
Beginning 1 month after RFA, patients undergo contrast-enhanced MRI for routine
post-ablation follow-up. MRI scans are performed at 1, 4, 7, 12, 18, and 24 months after
completion of RFA.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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