Colorectal Cancer Clinical Trial
Official title:
A Pre-Phase I Biodistribution Study Of hCC^CH2 Labeled With 131 Iodine In Patients With Gastrointestinal Adenocarcinomas
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and deliver
tumor-killing substances to them without harming normal cells. This may be an effective
treatment for gastrointestinal cancer.
PURPOSE: Phase I trial to study the effectiveness of radiolabeled monoclonal antibody
therapy in treating patients who have gastrointestinal cancer.
OBJECTIVES: I. Determine the biodistribution and biokinetics of iodine I 131-labeled
monoclonal antibody CC49-delta CH2 in patients with gastrointestinal adenocarcinoma. II.
Determine the human anti-human monoclonal antibody response in patients treated with this
drug.
OUTLINE: Patients receive iodine I 131-labeled monoclonal antibody CC49-delta CH2 (131I MOAB
CC49-delta CH2) IV over 5-10 minutes on day 0. Patients also receive unlabeled monoclonal
antibody CC49-delta CH2 IV over 5 minutes followed by 131I MOAB CC49-delta CH2 IV over 5-10
minutes on day 28. Patients are followed weekly for 4 months and then every 3 months for 1
year.
PROJECTED ACCRUAL: A total of 25 patients will be accrued for this study within 1 year.
;
Primary Purpose: Treatment
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