Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT06426745 |
Other study ID # |
PEG solution |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
November 1, 2022 |
Est. completion date |
December 1, 2023 |
Study information
Verified date |
May 2024 |
Source |
Egymedicalpedia |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
Colonoscopy is the current standard method for evaluation of colonic disorders such as
colorectal cancer, IBD, polyps, and other conditions.
Description:
Colonic cancers are a major concern in the Middle East and the world in general, and every
institute has attempted to initiate various clinical and investigatory procedures to detect
the disease early in its development. From 2005 till 2010 an audit conducted at the Royal
Liverpool University revealed that out of 8910 colonoscopies, 693 were incomplete (7.8%), and
for 25% of failure was because of inadequate bowel preparation.
An adequate bowel preparation regimen is not only effective in cleansing the colon but should
be well tolerated by patients. The polyethylene glycol (PEG) solution, an isosmotic
non-absorbable polymer, is generally used for bowel preparation, because of its safety,
effectiveness, and good tolerability. Quality of bowel cleansing depends not only on the
formula used, but the preparation regimen also plays a role. Split dosing of the laxative
offers, in general, better cleansing than a single dose preparation.
A large survey was also done in the USA in 2018 and demonstrated that split dose treatment
was more tolerable than single-dose treatment for bowel preparation.
Also more recent study shows split-dose bowel preparation for colonoscopy with PEG is better
than single-dose, in terms of adequate bowel preparation and polyp detection.
On the other hand , a large randomized trial of PEG regimens show, low-volume same-day
resulted in similar bowel cleanliness compared with high-volume or low-volume split-dosing.
Willingness to repeat and tolerability were superior with low-volume same-day compared with
high-volume split-dose and similar to low-volume split-dose. Another most recent one
demonstrated that same-day morning PEG regimen can be considered an effective well-tolerated,
and acceptable bowel preparation for colonoscopy.
A same-day dose of bowel cleanser has several benefits compared with split-dose or
previous-day dose: the fasting time is shorter and there is no sleep disturbance, which can
be associated with split-dose or previous-day regimen.