Clinical Trials Logo
  1. Home
  2. Colonic Polyp
  3. NCT03962868

Endoscopic Submucosal Dissection (ESD) Versus Endoscopic Mucosal Resection (EMR) for Large Non Pedunculated Colonic Adenomas: a Randomized Comparative Trial — RESECT COLON  

Colonic Polyp Clinical Trial

Official title:
Endoscopic Submucosal Dissection (ESD) Versus Endoscopic Mucosal Resection (EMR) for Large Non Pedunculated Colonic Adenomas: a Randomized Comparative Trial

Clinical Trial Summary

Initially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single fragment. It allows a perfect pathological analysis, and decreases the rate of recurrence of the adenoma to less than 2% However, this procedure, which is technically more challenging, is also more risky (perforation rate at 4% vs. 1% for WF-EMR) and longer. Submucosal dissection is also more expensive in terms of equipment, but this difference can be offset by the cost of the high number of iterative colonoscopies required in patients who have had endoscopic resection by WF-EMR. Scientific debate is agitating the Western world1,2 and Japanese experts do not perform WF-EMR anymore, whereas no comparative prospective study has compared these two procedures. We therefore propose to compare these two endoscopic resection strategies in terms of recurrence rate at 6 months and to estimate the differential cost-effectiveness and cost-utility ratios over a 36-month time horizon.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03962868
Study type Interventional
Source University Hospital, Limoges
Contact
Status Active, not recruiting
Phase N/A
Start date September 17, 2019
Completion date April 28, 2024
View Details
See also
  Status Clinical Trial Phase
Completed NCT03272945 - Linked-color Imaging for the Detection of Colorectal Flat Lesions N/A
Recruiting NCT06062095 - Computer Aided Diagnosis (CADx) for Colorectal Polyps Resect-and-Discard Strategy N/A
Not yet recruiting NCT02688699 - Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract Phase 4
Not yet recruiting NCT05776381 - The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp Phase 2
Recruiting NCT04157803 - Accuracy of aCETIC Acid to Predict Histopathology of Colonic Polyps N/A
Completed NCT03758872 - CUFF-assisted Colonoscopy vs Standard Colonoscopy
Recruiting NCT05870332 - Nationwide Study of Artificial Intelligence in Adenoma Detection for Colonoscopy
Completed NCT03690297 - Linked Color Imaging (LCI) for Colorectal Adenoma Detection N/A
Recruiting NCT03865537 - Cold Snare Endoscopic Mucosal Resection Trial N/A
Recruiting NCT04149184 - Computer-aided Detection Device in Standard Colonoscopy N/A
Recruiting NCT05099432 - The CARMA Technique Study N/A
Withdrawn NCT04778566 - Evaluating the Cologuard Test for Use in Lynch Syndrome
Withdrawn NCT01372696 - Endoscopic Characteristics of Colonic Tumours N/A
Recruiting NCT05322993 - Improving Polyp Detection Rate by Artificial Intelligence in Colonoscopy N/A
Completed NCT03121495 - Study on Second Forward View Examination in the Right Colon N/A
Completed NCT03344055 - Endocuff-assisted Colonoscopy vs Standard Colonoscopy on Adenoma Detection Rate N/A
Recruiting NCT06063720 - Effective Withdrawal Time and Adenoma Detection Rate
Recruiting NCT04220905 - Endoscopic Resection of Large Colorectal Polyps: An Observational Cohort Study
Completed NCT04693078 - Detection of Colonic Polyps Via a Large Scale Artificial Intelligence (AI) System N/A
Completed NCT05242562 - Effect of Low-volume (1L) vs Intermediate-volume (2L) Bowel Preparation on Cost-effectiveness and Quality of Life N/A