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Cognitive Symptoms clinical trials

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NCT ID: NCT04813965 Completed - Breast Cancer Clinical Trials

Breast Cancer Patients' Cognitive Symptoms After Information About Chemotherapy-Related Cognitive Symptoms

CONTEXT
Start date: March 20, 2014
Phase: N/A
Study type: Interventional

Previous cross-sectional studies have shown that informing cancer patients about potential chemotherapy-related cognitive symptoms may negatively affect perceived cognitive symptoms and verbal memory performance. A multicenter, randomized study in newly diagnosed breast cancer patients receiving (neo) adjuvant chemotherapy was performed to evaluate this Adverse Information Effect (AIE) over time and investigated whether inviting patients to self-affirm can reduce such AIEs on perceived cognitive symptoms and cognitive test performance.

NCT ID: NCT02144688 Terminated - Cognitive Symptoms Clinical Trials

COMO: Cognition Study With HIV+ Patients (CTNPT 015)

COMO
Start date: June 2011
Phase: Phase 0
Study type: Interventional

The purpose of this study is to contribute evidence towards the potential to improve cognition in HIV+ individuals experiencing cognitive decline through personalized change in antiretroviral (ARV) medication. To that end, following a comprehensive evaluation to identify confounding clinical conditions, study participants will undergo a lumbar puncture to: (i) measure viral load (at 2 copies/ml); (ii) identify Cerebrospinal Fluid (CSF) genotype and tropism; and (iii) measure concentration of antiretroviral agents. When indicated from the CSF analysis, a personalized change in ARV will be implemented. Cognition will be measured in all at study entry and 6 months later.

NCT ID: NCT01578083 Completed - Cognitive Symptoms Clinical Trials

Chemotherapy-Induced Cognitive Impairment

CICI
Start date: April 2012
Phase: N/A
Study type: Observational

The investigators overall research hypothesis is that systemic chemotherapy induces structural changes in the white matter of the brain as demonstrated with Diffusion Tensor Imaging (DTI) and functional changes in well-defined cortical neural networks as demonstrated by resting-state functional connectivity MRI (rs-fcMRI). The investigators believe these structural and functional changes are responsible for the cognitive symptoms associated with chemotherapy-induced cognitive impairment (CICI). The Specific Aim for this study is: To assess the impact of chemotherapy on structural white matter as defined by DTI and functional cognitive networks as defined by rs-fcMRI by comparing a sample of breast cancer survivors with self-reported CICI to breast cancer survivors without CICI. Hypothesis: Post-chemotherapy breast cancer patients with self-reported CICI will have abnormal structural connections characterized by DTI-defined disruptions in fractional anisotropy (FA) and mean diffusivity (MD) and abnormal functional connectivity characterized by rs-fcMRI-defined disruptions in cognitive networks when compared to patients without self-reported CICI.

NCT ID: NCT01333215 Recruiting - Suicide, Attempted Clinical Trials

Study of Cognitive Inhibition Disorders in Depressed Older Suicide Attempters

ETIC
Start date: December 2010
Phase: N/A
Study type: Observational

The purpose of this study is to compare the cognitive inhibition deficit among depressed older suicide attempters compared to depressed older suicide non-attempters.

NCT ID: NCT01138020 Active, not recruiting - Clinical trials for Traumatic Brain Injury

Cognitive Rehabilitation of Blast Traumatic Brain Injury (TBI)

CRbTBI
Start date: March 1, 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the efficacy of a structured rehabilitation program on cognitive function and quality of life in individuals with blast-induced traumatic brain injury (bTBI).

NCT ID: NCT00391378 Completed - Stroke Clinical Trials

Cerebral Lesions and Outcome After Cardiac Surgery (CLOCS)

Start date: September 9, 2006
Phase: N/A
Study type: Observational

Between 1 and 5 percent of patients who have coronary artery bypass surgery suffer a stroke following surgery, and 30 percent have new brain lesions that do not produce symptoms and are seen only on MRI. In addition, up to 40 percent of patients develop long-term cognitive impairment. This study will identify risk factors that predict whether a person undergoing heart surgery will develop cerebral infarcts after surgery. It will also identify operative and inflammatory factors that may alter the risk, and will evaluate whether the small lesions are associated with cognitive decline at 6 months. People 18 years of age or older who will undergo coronary artery bypass surgery (CABG), heart valve replacement, or combined CABG and valve replacement procedure are eligible for this study. Candidates must have no neurological or cognitive impairment before surgery. Participants will undergo standard medical and surgical treatment as determined by their physicians. In addition, they have the following procedures: - Medical and neurological evaluation before surgery and 24 and 48 hours after surgery. - Brain MRI before surgery, and 48 hours, 30 days and 6 months after surgery. - Blood draws before surgery, immediately after surgery, and 6, 24, 48 and 72 hours after surgery to quantify the response of their inflammatory system to surgery. - Neuropsychological examinations 30 days and 6 months after surgery. - In addition, patients who agree to enroll in a substudy that will explore whether differences in the genes coding for inflammatory molecules lead to a change in the risk of iscjhemia after heart surgery, will have extra blood drawn for genetic analysis.

NCT ID: NCT00387062 Completed - Breast Cancer Clinical Trials

Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment

Start date: October 2006
Phase: Phase 1
Study type: Interventional

The investigators hypothesize that continuous active interaction with environments that are demanding to sensory, cognitive, and motor systems, together with imbedded rewards for successful performance, will help improve memory and cognitive functioning in patients suffering from "chemobrain".

NCT ID: NCT00138021 Active, not recruiting - Schizophrenia Clinical Trials

Cognitive Remediation in Supported Employment at Human Service Center (HSC)

CT+SE
Start date: July 2005
Phase: N/A
Study type: Interventional

This project seeks to evaluate the feasibility and effectiveness of combining cognitive remediation and Supported Employment Program (SEP) services to improve work outcomes in people with a serious mental illness who have been unable to benefit from vocational services (i.e., acquire or maintain a job). Cognitive remediation involves treating and improving cognitive impairments, such as memory (e.g., short-term and working memory), attention span, or problem solving skills. It is hypothesized that cognitive remediation will significantly improve peoples' employment outcomes in a supported employment program.

NCT ID: NCT00134953 Terminated - Cognitive Symptoms Clinical Trials

Efficacy and Safety of Rivastigmine in Patients With Mild Cognitive Impairment

Start date: January 2003
Phase: Phase 3
Study type: Interventional

This study is designed to investigate the efficacy and safety of rivastigmine compared with placebo in patients with mild cognitive impairment (MCI).

NCT ID: NCT00111267 Completed - Cognitive Decline Clinical Trials

Oral Vitamin B12 Supplementation and Cognitive Performance in Elderly People

Start date: May 2003
Phase: N/A
Study type: Interventional

The purpose of this trial is to study the effects of oral vitamin B12 supplementation and vitamin B12 combined with folic acid supplementation on cognitive performance for 24 weeks in elderly people with mild vitamin B12 deficiency.