Clinical Trials Logo
  1. Home
  2. Cognitive Function
  3. NCT03208569
  4. Details
NCT03208569 Clinical Trial

Anticholinergic Burden - Treatment Optimization

Cognitive Function Clinical Trial

Official title:
Treatment Optimization Regarding Anticholinergic Medications Potential Impact on Cognitive Test Performance

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03208569
Other study ID # Studie ACB
Secondary ID
Status Completed
Phase
First received
Last updated
Start date September 1, 2017
Est. completion date September 30, 2021

Study information
Verified date October 2021
Source Region Skane
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

There is increasing evidence that medications with anticholinergic effects may adversely affect cognitive function. Older adults are particularly sensitive to anticholinergic effects because of changes in pharmacokinetics and pharmacodynamics. The cumulative effect of taking one or more medicines with anticholinergic properties is referred to as anticholinergic burden. To estimate the anticholinergic burden, Boustani et al. published the Anticholinergic Cognitive Burden scale (2008). The objective of this study is to measure the association between the use of medications with anticholinergic properties (identified by the ACB scale) and cognitive performance. Anticholinergic use and cognitive performance will be measured at baseline and 6-months follow-up.

Recruitment information / eligibility
Status Completed
Enrollment 665
Est. completion date September 30, 2021
Est. primary completion date September 30, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 50 Years and older
Eligibility Inclusion Criteria: - 50 years and older

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Sweden Specialistminnesmottagningen Ängelholm

Sponsors (2)
Lead Sponsor Collaborator
Region Skane Angelholm Hospital

Country where clinical trial is conducted

Sweden, 

References & Publications (1)

Rube T, Ecorcheville A, Londos E, Modig S, Johansson P. Development of the Swedish anticholinergic burden scale (Swe-ABS). BMC Geriatr. 2023 Aug 25;23(1):518. doi: 10.1186/s12877-023-04225-1. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Cognitive function Cognitive function, measured by the Mini-Mental State Examination (MMSE) 6 months
Secondary Anticholinergic burden Anticholinergic burden, determined according to the Anticholinergic Burden scale 6 months
Secondary Cognitive function Cognitive function, measured by Montreal Cognitive Assessment (MOCA) 6 months
Secondary Cognitive function Cognitive function, measured by the Trail Making Test A & B (TMT) 6 months
Secondary Cognitive function Cognitive function, measured by The Alzheimer´s Disease Assessment Scale - Cognitive subscale (ADAS-Cog) 6 months
Secondary Cognitive function Cognitive function, measured by the Symbol Digit Modalities Test (SDMT) 6 months
Secondary Cognitive function Cognitive function, measured by A Quick Test of cognitive speed (AQT) 6 months
See also
  Status Clinical Trial Phase
Recruiting NCT05563805 - Exploring Virtual Reality Adventure Training Exergaming N/A
Completed NCT03708692 - Menstrual Cycle Phases on Recovery and Cognitive Function
Active, not recruiting NCT04505345 - Virtual Reality Cognitive Training in Alcohol Use Disorder N/A
Completed NCT04430465 - Effects of Wholegrains on Children's Health (KORN) N/A
Completed NCT02915913 - Effects of Exercise Training on Cognitive Function and Neurotrophic Factors in Overweight Adults N/A
Completed NCT01410097 - Physical and Cognitive Function - Look AHEAD Ancillary Study N/A
Completed NCT03826121 - Efficacy and Safety of Sesame Oil Cake Extract on Improvement of Cognitive Function N/A
Recruiting NCT05621278 - Children to Adults Mental and Psychosomatic Health Study (CAMPS)
Completed NCT05498415 - Feasibility, Acceptability, and Efficacy of the Sleep Move Stand Study N/A
Completed NCT03793777 - The Effect of Aronia Melanocarpa Extract on Cognitive Function N/A
Recruiting NCT05525299 - Reminiscence-Based Life Review on Copying With Existential Suffering Among Older Cancer Survivors N/A
Completed NCT03698123 - Performance Nutrition for Residents and Fellows N/A
Completed NCT04543500 - Self-regulation of Prefrontal Cortex During Emotional Cognitive Control N/A
Recruiting NCT05891977 - Effect of Tomato Paste Consumption on the Microbiota-gut-brain Axis in Healthy Adults N/A
Recruiting NCT05591885 - Nutrilite Memory Builder on the Improvement of Cognitive Function N/A
Active, not recruiting NCT05575752 - Acute Health Effects of High Temperature Exposure N/A
Completed NCT03716609 - Effects of Magnesium Supplementation on Hemodynamic Parameters and Cognitive Function N/A
Completed NCT02763514 - The Effects of DHA- and EPA-enriched Oils on Cognitive Function and Mood N/A
Completed NCT02675621 - Investigation of Acute Mood and Cognitive Performance Effects of Beverages Containing Phenolics in Healthy Adults N/A
Completed NCT02344056 - Cognition Intervention Study Dortmund- Continued (Coco) N/A

External Links