Clinical Trials Logo

Clinical Trial Summary

Using a double-blind randomized controlled trial design, this study intends to evaluate the short-term effect of magnesium citrate on cognitive functions and hemodynamic parameters in MCI elders, including Montreal Cognitive Assessment, working memory test-digit span test, carotid artery flow velocity, ankle-brachial blood pressure ratio, and urinary magnesium.


Clinical Trial Description

Dementia is an important geriatric syndrome. The prevalence of dementia increases with age. According to the data of the Taiwan Alzheimer Disease Association, one out of 13 elderly people over 65 and one out of 5 elderly over 80 had dementia. Almost 20% of the elderly people have the mild cognitive impairment (MCI), an intermediate stage between normal cognition and dementia. The results from the Nutrition and Health Survey in Taiwan (NAHSIT), 2013-2016 found that magnesium average intake was much lower than the daily recommended intake level in MCI elders over 65. Since magnesium, an abundant essential mineral in human body plays important roles in energy provision, anti-inflammation, and preventing post-stroke NMDA toxicity; our previous study trialed and showed that a moderate level of daily magnesium supplementation could improve stroke recovery for discharged stroke patients in a 6-month clinical trial. Due to its effect on neuroprotection, this study intends to evaluate the short-term effect of magnesium supplement at a DRI level on cognitive function and on certain hemodynamic parameters. MCI participants aged 60 and over are eligible for recruitment. The Mini-Mental State Examination (MMSE) will be used to determine the MCI status. A score of 25 or lower is indicative of cognitive impairment. The exclusion criteria include: regularly taking magnesium supplements, having a severe illness (e.g. cancer), bed-ridden, inability to speak, with visual or hearing impairment, and living in elderly homes. The investigators designed a double-blind randomized controlled trial. Participants will be divided into magnesium intervention group and placebo group. Participants of the placebo group will receive 30cc solution containing 100 mg of citrate acid and flavored by 1g of Splenda. The magnesium citrate pure powder from NOW FOODS containing 300mg magnesium will be dissolved in 30cc of the above solution. Before and after two hours of intervention, participants will be interviewed and assessed for the following: questionnaires, cognitive function, carotid artery flow velocity, ankle-brachial blood pressure ratio, and urinary magnesium. Questionnaires include Montreal Cognitive Assessment (MoCA) and working memory test - digit span test. Philips iE33 Ultrasound System and OMRON Non-invasive Vascular Screening Device VP1000 plus will be used to measure carotid artery flow velocity and ankle-brachial blood pressure ratio. This intervention will be carried out after the informed consent form is signed, roughly from 8 AM in the morning to 12:30 PM. Participants have to take their breakfast before the trial and allowed to eat lunch after the process finishes. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03716609
Study type Interventional
Source Academia Sinica, Taiwan
Contact
Status Completed
Phase N/A
Start date October 23, 2018
Completion date June 30, 2021

See also
  Status Clinical Trial Phase
Recruiting NCT05563805 - Exploring Virtual Reality Adventure Training Exergaming N/A
Completed NCT03708692 - Menstrual Cycle Phases on Recovery and Cognitive Function
Active, not recruiting NCT04505345 - Virtual Reality Cognitive Training in Alcohol Use Disorder N/A
Completed NCT04430465 - Effects of Wholegrains on Children's Health (KORN) N/A
Completed NCT02915913 - Effects of Exercise Training on Cognitive Function and Neurotrophic Factors in Overweight Adults N/A
Completed NCT01410097 - Physical and Cognitive Function - Look AHEAD Ancillary Study N/A
Completed NCT03826121 - Efficacy and Safety of Sesame Oil Cake Extract on Improvement of Cognitive Function N/A
Recruiting NCT05621278 - The Longitudinal Study of Mental Health in Child to Adult
Completed NCT05498415 - Feasibility, Acceptability, and Efficacy of the Sleep Move Stand Study N/A
Completed NCT03208569 - Anticholinergic Burden - Treatment Optimization
Completed NCT03793777 - The Effect of Aronia Melanocarpa Extract on Cognitive Function N/A
Recruiting NCT05525299 - Reminiscence-Based Life Review on Copying With Existential Suffering Among Older Cancer Survivors N/A
Completed NCT03698123 - Performance Nutrition for Residents and Fellows N/A
Completed NCT04543500 - Self-regulation of Prefrontal Cortex During Emotional Cognitive Control N/A
Recruiting NCT05891977 - Effect of Tomato Paste Consumption on the Microbiota-gut-brain Axis in Healthy Adults N/A
Recruiting NCT05591885 - Nutrilite Memory Builder on the Improvement of Cognitive Function N/A
Active, not recruiting NCT05575752 - Acute Health Effects of High Temperature Exposure N/A
Completed NCT02763514 - The Effects of DHA- and EPA-enriched Oils on Cognitive Function and Mood N/A
Completed NCT02675621 - Investigation of Acute Mood and Cognitive Performance Effects of Beverages Containing Phenolics in Healthy Adults N/A
Completed NCT02277002 - Commuter Air Pollution Intervention Study N/A