Cognitive Function Clinical Trial
— CAPIOfficial title:
Reducing Commuter Air Pollutant Exposure by Cabin Air Filtration
Verified date | February 2015 |
Source | Health Canada |
Contact | n/a |
Is FDA regulated | No |
Health authority | Canada: Health Canada |
Study type | Interventional |
Traffic related air pollution is a well-recognised and much studied contributor to smog and
is linked to a number of adverse health outcomes. Although traffic pollutants can travel
long distances, exposure to the highest levels of the raw emissions can occur closest to the
source; e.g. in a car in dense traffic conditions. Time spent in-vehicle may contribute up
to half of commuters' daily exposure to certain air pollutants. Most new cars now have or
allow for a cabin air filter, but it is not known how well cabin air filtration can reduce
exposure to traffic-related air pollution.
This intervention study will measure commuters' exposure to air pollutants in rush hour
traffic. It will evaluate the impact of this exposure on stress hormones in saliva, and
short term cardiopulmonary health indicators such as blood pressure, heart rate variability
and respiratory inflammation. It will also look at effects on cognition (mental processing
and judgement) in this real world environment where any deficit could be important to
safety. In addition, the study will examine whether cabin air filtration can reduce the
exposure to traffic related air pollutants and result in improvements in short term
cardiopulmonary and cognitive function. This research will contribute to our understanding
of how this environment contributes to Canadians' overall air pollution exposure as well as
the potential health impacts. It will also test a potentially valuable and economical means
of reducing exposure to traffic related air pollution in a commuting environment. The study
may also guide the future implementation of the use of cabin filters as an exposure
reduction intervention.
Overall Project Objectives:
Can cabin air filtration effectively reduce exposure to traffic related air pollution? Does
commuter exposure to air pollution affect short term stress, and cardiopulmonary and
cognitive function? Can cabin air filtration mitigate the health effects of commuters'
exposure to air pollution?
Status | Completed |
Enrollment | 48 |
Est. completion date | November 2014 |
Est. primary completion date | November 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Healthy Individuals; - non-smoking. Exclusion Criteria: - Smokers; - living in a smoking household; - currently experiencing seasonal allergies; - suffering from heart rhythm problems or heart conditions; - regularly taking corticosteroid medication; - pregnant or breastfeeding; - allergic to latex; - sensitivity to adhesives |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Canada | Guy-Favreau Complex | Montreal | Quebec |
Lead Sponsor | Collaborator |
---|---|
Health Canada |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Variation in cardiopulmonary function | Heart Rate Variability (HRV) will be measured from continuous ambulatory electrocardiogram (ECG) recordings collected during the study protocol. ECG will be worn for the duration of the study day period (approximately 5 hours), including a period prior to exposure and following exposure. | 5 hours | No |
Secondary | Changes in neuropsychological Function | Assessment of neuropsychological function can be achieved using a battery of mood and cognitive tests. The study will use a battery of tests that are comercially available through CANTAB, the mini-mental state exam designed by University of Cambridge. Battery will be administered before and after exposure. | 5 hours | No |
Secondary | Changes in endothelial function | Endothelial function will be assessed using the non-invasive, FDA approved Endo-Pat2000 instrument. Test administration involves continuous measurement of blood flow and vascular tone in the fingertips of both index fingers, before, during and after an occlusion of blood flow to the non-dominant hand. Blood flow is occluded using a standard blood pressure cuff positioned on the upper arm. Measures will be carried out before and after exposure. | 5 hours | No |
Secondary | Changes in levels of Hypothalamic-Pituitary-Adrenal (HPA) Axis | In the present study, salivary cortisol will be assessed as a non-invasive measure of HPA axis activation. Saliva sample collection will be done with Salivette swabs twice before exposure, once during exposure and twice following exposure. | 5 hours | No |
Secondary | Fraction of Exhaled Nitric Oxyde | Lung inflammation will be assessed as the fraction of nitric oxide (NO) exhaled in the participants' breath using a portable, FDA approved, fractional exhaled nitric oxide (FENO) measurement device, the NIOX Mino. Measures will be carried out before and after exposure. | 5 hours | No |
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