Multiple Sclerosis Clinical Trial
Official title:
Effect of Transcutaneous Electrical Nerve Stimulation on Cognitive Disorders in Multiple Sclerosis Patients
The aim of this study is to evaluate whether the Transcutaneous Electrical Nerve Stimulation (TENS) is effective on improvement of cognitive disorders in Multiple sclerosis patients.
Multiple sclerosis (MS) is one of the most common autoimmune diseases in the world. One of
the complications of MS, is cognitive disorder.
In some studies on rats, stimulation of somatosensory neurons has improved the hippocampus
activity by increasing the amount of acetylcholine. Hippocampus has a major role in
cognition and behavior.
TENS is a non-invasive method in which the electrical pulses are sent to the body trough
skin by electrodes. This device can stimulate the somatosensory neurons by electrical
impulses. In several studies, the effect of TENS has been proved on short term memory and
verbal fluency in patients with mild stages of Alzheimer disease. Also it has been effective
on some aspects of cognition on old people suffering from forgetfulness.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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