Cognitive Aging Clinical Trial
Official title:
Effects of Blueberry Juice Consumption on Brain Activation and Perfusion in Healthy Older People
Verified date | September 2016 |
Source | University of Exeter |
Contact | n/a |
Is FDA regulated | No |
Health authority | UK: University of Exeter |
Study type | Interventional |
Blueberries are rich in flavonoids that possess antioxidant and anti-inflammatory properties, which in rodent models are neuro-protective. The risk of developing dementia is reduced in people habitually consuming high flavonoid intakes, but data from human intervention studies is sparse. We therefore investigated whether 12 weeks of blueberry concentrate supplementation improved cognitive function in healthy elderly via increased brain activation and perfusion.
Status | Completed |
Enrollment | 26 |
Est. completion date | September 2014 |
Est. primary completion date | September 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 60 Years to 80 Years |
Eligibility |
Inclusion Criteria: - aged 60-80y - Addenbrooke's Cognitive Examination III questionnaire > 88 - Consuming 5 or less portions of fruit per day Exclusion Criteria: Addenbrooke's Cognitive Examination III questionnaire < 88 Contraindications for MRI Consuming more than 5 portions of fruit per day |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University of Exeter |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Brain perfusion | MRI - arterial spin labelling | Change from baseline to 12 weeks dietary supplementation | No |
Secondary | Brain activation | fMRI whilst performing modified Stroop task | Change from baseline to 12 weeks dietary supplementation | No |
Secondary | Cognitive function tests | Cogstate battery of tests | Change from baseline to 12 weeks dietary supplementation | No |
Secondary | Blood biomarkers of inflammation | CRP, IL6, | Change from baseline to 12 weeks dietary supplementation | No |
Secondary | Blood biomarkers of oxidative stress | protein carbonyls, glutathione | Change from baseline to 12 weeks dietary supplementation | No |
Secondary | Blood biomarkers of neurogenesis | BDNF | Change from baseline to 12 weeks dietary supplementation | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03988829 -
Strategic Training to Optimize Neurocognitive Functions in Older Adults
|
N/A | |
Completed |
NCT03141281 -
Intervention Comparative Effectiveness for Adult Cognitive Training
|
N/A | |
Completed |
NCT05980286 -
Impact of Musical Improvisation Training on Cognitive Function in Older Adults
|
N/A | |
Active, not recruiting |
NCT02977819 -
Study in Cognitively Intact Seniors Aiming to Assess the Effects of Meditation Training
|
N/A | |
Completed |
NCT02714426 -
A 14 Week Study of Mindfulness Effects on Attentional Control in Older Adults
|
N/A | |
Completed |
NCT05462977 -
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
|
N/A | |
Recruiting |
NCT05322343 -
Biobank and Brain Health in Bordeaux.
|
||
Completed |
NCT00935493 -
Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
|
N/A | |
Completed |
NCT00599508 -
Nutritional Supplementation in Cognitive Aging
|
N/A | |
Active, not recruiting |
NCT05455229 -
Elucidating How Physical Activity and Sleep Relate to Optimal Cognitive Ageing
|
||
Terminated |
NCT04922710 -
Physical Exercise for Augmenting Cognitive Health (PEACH)
|
Early Phase 1 | |
Recruiting |
NCT06006962 -
Aging Well Through Interactions and Scientific Education - Action Plan (AgeWISE-AP)
|
N/A | |
Completed |
NCT04904991 -
Three-month Chan-Chung Qigong Improves Physical Function Performance and Quality of Life
|
N/A | |
Completed |
NCT05672771 -
The Effects of Mixed Working Memory Training on Subsequent Training Gains Among Older Adults
|
N/A | |
Completed |
NCT03629912 -
Bingocize: A Novel Mobile Application for Older Adult Health
|
N/A | |
Recruiting |
NCT04018092 -
The Revitalize Study in Older Adults at Risk for Alzheimer's Disease
|
Phase 2 | |
Completed |
NCT03677726 -
Improving Sleep Continuity Through Mindfulness Training for Better Cognitive Ageing.
|
N/A |