Cognitive Aging Clinical Trial
Official title:
Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
This proposal aims to determine whether low does of the alpha-2A-adrenoceptor agonist guanfacine can improve deficits in prefrontally-mediated cognitive functions in healthy elderly subjects.
Primary:
- To determine whether low does of the α2A-adrenoceptor agonist guanfacine can improve
deficits in prefrontally-mediated working memory and executive control functions, in
healthy elderly subjects. Subjects will be randomly assigned to receive placebo or
guanfacine at one of two dose levels: 0.1 mg, or 0.5 mg daily at bedtime in
double-blind fashion for twelve weeks.
Secondary:
- To determine whether guanfacine can favorably influence global status and quality of
life (QOL) in healthy elderly subjects.
- To determine whether low-dose guanfacine is safe and well-tolerated in healthy elderly
subjects.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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